葡萄柚和柚子不是影响药物代谢的唯一水果。
Grapefruit and pomelo aren't the only fruits that affect drug metabolism.
药物代谢研究是新药开发中不可缺少的一项。
Metabolic study is an indispensable part to the development of new drugs.
目的：为了促进药物代谢酶在临床上的深入研究。
Objective: To promote the study of drug metabolic enzymes in clinical practice.
CYP3A29是猪肝脏最重要的药物代谢关键酶。
CYP3A29 is the most important key enzyme for drug metabolism in pig's liver.
肝亚细胞成分是研究药物代谢及种属差异的较好体外模型。
The results suggest that hepatic subcellular fractions are useful as in vitro models for species difference study.
目的：综述近年来中药有效成分对药物代谢酶的影响的研究进展。
Objective: To review the effects of the active components of Chinese herbs on drug metabolizing enzymes.
肾功能减退时，不但药物排泄缓慢，而且药物代谢也会发生改变。
When renal function declined, drug excretion slow, and drug metabolism altered.
目的研究酮康唑对沙奎那韦的体外代谢和药物代谢动力学的影响。
Aim to investigate the effect of ketoconazole on the metabolism in vitro and pharmacokinetics of saquinavir.
目的本论文旨在考察两种中药对抗艾滋病化学药物代谢环节潜在影响。
Objective:To investigate potential effects of some natural drugs on pharmacokinetics of anti-AIDS chemical drugs.
目的观察粗叶悬钩子粗多糖对模型大鼠急性肝损伤药物代谢酶的影响。
Objective To investigate the effect of polysaccharide of Rubus alceaefolius Poir on drug-metabolizing enzyme in acute liver injury rats.
结论：药物代谢酶的认识和研究有助于临床合理用药和减少药物不良反应。
Conclusion: the study of drug metabolic enzymes will help to provide safe, rational and effective prescriptions and to decrease the adverse drug reactions.
肠道转运体、肝脏药物代谢酶及肾脏在药物adme过程中发挥着重要作用。
Intestinal drug transporters, hepatic drug metabolic enzymes and the kidney play a very important role in the process of ADME.
结论大鼠原位肝灌流是良好的整体器官药物代谢模型，是体外实验有力的补充。
CONCLUSION In situ liver perfusion is an appropriate organ model for drug metabolism and disposition research.
体外培养的原代肝细胞被广泛用于药物代谢、药物间相互作用和药物肝毒性的研究。
Primary cultures of hepatocytes have been extensively used for evaluation of drug metabolism, drug-drug interactions and drug hepatotoxicities.
结果提示镉、铅、汞可能通过降低微粒体酶的新生合成，抑制肝微粒体药物代谢酶。
The results suggested that the inhibition of hepatic microsomal drug-metabolizing enzymes by cadmium, lead or mercury was produced by decreased neosynthesis of microsomal enzymes.
这些试验中的相关的药物代谢动力学和机械学的研究将会考虑到优化药物定量和监测。
Linked pharmacokinetic and mechanistic studies within these trials will allow for optimizing drug dosing and monitoring.
短期和长期安全性评价和预测非常重要，同样重要的还有佐剂本身的药物代谢动力学评价。
Short-term and long-term safety evaluation and prediction are important, as is the evaluation of the pharmacokinetics of the adjuvant alone.
通过比较，发现凝胶包埋细胞比单层贴壁培养细胞能更好地保持各项药物代谢酶的活性。
By comparison of enzyme activitys in gel entrapment and monolayer culture, it was concluded that cells of gel entrapment can maintain these enzyme activity better than those of monolayer.
这次综述提供了一个对大多数药物代谢有关的酶为重点的细胞色素P 450系统的了解。
This review provides a better understanding of the cytochrome P450 system with a focus on those enzymes most involved in drug metabolism.
目的：建立一种简便、经济、高效分离原代大鼠肝细胞的方法，适用于体外药物代谢研究。
Objective: to develop a convenient, inexpensive and efficient method for isolation of functional primary rat hepatocytes, which can be used successfully for in vitro metabolism study.
方法选用7株丝状真菌为转化菌株，利用液相色谱质谱联用技术对药物代谢产物进行检测。
Method Metabolites produced by 7 filamentous fungi screened were identified by liquid chromatography-tandem mass spectrometry (LC-MSn).
根据动物实验来预测人体的药物代谢时，代谢酶的种属差异性会使这项研究工作变得非常困难。
Predicting of drug metabolism in humans based on animal experiments is complicated by species differences in the catalytic properties of these enzymes.
药物代谢所致的药相互作用，魏晓雄博士， 旅美中国药学家学会，美国食品和药物管理局。
Metabolic Drug Interactions in Drug Development, Xiaoxiong Wei, M. D. , Ph. D. , Food and Drug Administration, Association of Chinese-American Pharmaceutical Scientist, MD, USA.
细胞色素P 4503A (CYP3A)是参与临床药物代谢的主要CYP同工酶之一。
Cytochrome P450 3a (CYP3A) is one of the key isoenzymes involved in the metabolism of clinical drugs.
根据少数关于柚子对药物代谢影响的研究，看起来柚子和柚子汁像葡萄柚和葡萄柚汁一样起作用。
From the handful of studies on the effects of pomelo on drug metabolism, it looks like pomelo and pomelo juice act much like grapefruit and grapefruit juice.
巴格列酮已经经过一系列临床前期药效药理学、安全药理学、药代动力学或毒性动力学和药物代谢研究的评估。
Balaglitazone has been evaluated in a series of preclinical efficacy pharmacology, safety pharmacology, pharmacokinetic/toxicokinetic, and drug metabolism studies.
综述了目前HPLC-NMR联用技术在药物代谢研究，天然产物分析以及食品分析等方面的应用。
The application of HPLC-NMR in drug metabolism, natural products analysis and food analysis were reviewed.
综述了目前HPLC-NMR联用技术在药物代谢研究，天然产物分析以及食品分析等方面的应用。
The application of HPLC-NMR in drug metabolism, natural products analysis and food analysis were reviewed.
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