本发明还涉及在转基因小鼠中响应抗原激发产生全功能性仅有重链的抗体的方法。
The present invention also relates to a method of generation of fully functional heavy chain-only antibodies in transgenic mice in response to antigen challenge.
结论成功建立了TRPV 1转基因小鼠模型，为深入研究TRPV1的功能提供了更好的条件。
Conclusion TRPV1 transgenic mice have been established successfully. The model will contribute to the further research of the physiological function of TRPV1.
目的：为分析慢病毒介导的转基因小鼠中外源基因整合位点的信息，应用反向PCR克隆整合位点序列。
Objective: To investigate the information of transgene integrations in mice mediated with lentiviral vectors, the inverse PCR was used to clone the sequences of integration sites.
结论：HNYCF可以改善APP转基因小鼠的学习记忆能力，其作用机制可能与抗炎、抗氧化作用有关。
CONCLUSION: HNYCF evidently ameliorates the learning and memory ability in APP transgenic mice, which may be related to the anti-inflammatory and anti-oxidation effects of HNYCF.
方法APP695转基因小鼠分为AD模型组和益智汤治疗组，同月龄同背景转基因阴性小鼠为正常对照组。
Methods 3month old APP695 transgenic mice were randomly divided into model and Yizhi treatment groups, and negative transgenic mice were selected into normal control group.
结果转基因小鼠脑中NO与对照组无显著性差异；原位细胞凋亡检查也未发现转基因组与对照组有显著性差异。
Results NO significant differences of NO in the transgenic mice's brain and in-situ apoptosis were found when compared with those of the control group.
经蛋白免疫印记法证实，与同窝野生型小鼠相比，转基因小鼠的脑组织和肌肉组织中TRPV1的表达显著升高。
As detected by Western blotting, TRPV1 expressions in the brain and skeletal muscle of the transgenic mice were significantly higher than the wild-type littermates.
目的探讨针对乙型肝炎病毒（HBV）x、p双靶区反义RNA对乙型肝炎病毒转基因小鼠HBV复制和表达的影响。
Objective To investigate the effect of dual-target antisense RNA of hepatitis B virus (HBV) targeted to X and P region on replication and expression of HBV gene in HBV transgenic mice.
研究者利用IBD自发转基因小鼠来进行试验，随后这些小鼠进展为肠炎相关性结肠癌，两种疾病均可产生异常增生的人类MUC1蛋白。
The researchers tested transgenic mice that spontaneously develop IBD and then progress to colitis-associated colon cancer, producing the human version of MUC1 in both disease states.
并且如果这还不够令人震惊，第三代中的一些小鼠毛发甚至生长在嘴里——一种罕见的现象，但显然在食用转基因大豆仓鼠中，这种现象更普遍。
And if this isn't shocking enough, some in the third generation even had hair growing inside their mouths-a phenomenon rarely seen, but apparently more prevalent among hamsters eating GM soy.
为了分析AIC649抗病毒的疗效，研究人员给予转基因乙肝小鼠每周两次的 AIC649或“金标准”替诺福韦每日两次或用安慰剂治疗，疗程持续29天。
To analyze the antiviral efficacy, hepatitis B transgenic mice were treated either twice-weekly with AIC649 or twice daily with "gold standard" Tenofovir or vehicle over a period of 29 days.
结果提示，选育双重杂合子转基因后代小鼠，是一条提高转基因动物外源基因表达水平的有效途径。
These results indicated that the selection of double heterozygotes among offspring may be a useful way to improve the expression of exogenous genes in the transgenic animals.
结果提示，选育双重杂合子转基因后代小鼠，是一条提高转基因动物外源基因表达水平的有效途径。
These results indicated that the selection of double heterozygotes among offspring may be a useful way to improve the expression of exogenous genes in the transgenic animals.
应用推荐