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Forest says clinical trials involving 1, 100 patients show that a low, 10-milligram dose of Lexapro is as effective at relieving depression as a 40-mg dose of Celexa.
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In one study, the average weight loss for a group taking a higher dose (32 mg) of naltrexone plus bupropion for about a year was 6.1% while for a lower dose (16 mg) it was 5%. (People taking a placebo had an average weight loss of 1.3%.) However, only half the participants who started the trial actually finished it.
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Patients will either receive 40 milligrams of Zocor, the second-highest dose, or a dose of Vytorin that combines 40 mg of Zocor with 10 mg of Zetia.
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But a 25 mg dose of propofol alone would have been considered relatively small, he said.
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Due to recent restrictions placed on the use of the 80 mg dose because of a higher risk of muscle toxicity, there will not be a FDC using this dose.
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The label recommends a daily dose of Qsymia containing 7.5 mg of phentermine and 46 mg of extended-release topiramate.
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By itself, the absence of the 80-mg dose probably wouldn't have a great impact on Crestor's sales, Arnold wrote.
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We do know that caffeine is safe in lower dose ranges from 100-300 mg a day, which is typically contained in several cups of coffee.
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An earlier study of the same size and design had shown a 73% reduction on the 80 mg dose and an 83% reduction on the 160 mg dose.
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