The Aquadex still "isn't ready for prime time, " argues Keith Aaronson, a heart specialist at the University of Michigan.

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Michael Davidson, a heart specialist at Rush University Medical Center in Chicago and a tester of the combo pill, predicts "a brutal three-way war" for market share among Vytorin, Lipitor and AstraZeneca's Crestor.

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After its opening in 1994 as a specialist heart surgery centre, the anticipated patient numbers at the hospital failed to materialise.

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"Essentially, this was a death sentence, " said Dr. John Harold, a Los Angeles heart specialist who is president of the College of Cardiology.

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Oz quickly established himself as a heart-transplant specialist.

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Lead signatory Mark Darowski, a children's intensive care specialist at the LGI, said if paediatric heart surgery in Leeds did end it would mean a three-fold rise in journey times for children needing urgent treatment.

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Ellen Mason, a cardiac nurse at the British Heart Foundation, warned that providing specialist heart screening could be problematical.

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Olivia was then transferred to Hope Hospital to see a kidney specialist and to have an operation, but had two heart attacks on the way, and later died.

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