Lisinopril, an ACE inhibitor, is commonly given to heart failure patients already, but in relatively low doses.

BBC: Heart drug offers hope to millions

Also, people on the diuretic had fewer fatal strokes than those who had been taking the ACE inhibitor.

FORBES: Comparative Effectiveness: Hope Or Hype?

In the study, Tekturna was given in addition to optimal cardiovascular treatment including an ACE inhibitor or ARB.

FORBES: ALTITUDE Study of Aliskiren Terminated Early by Novartis

The company is also recommending that physicians not prescribe drugs containing aliskiren with either an ACE inhibitor or an ARB.

FORBES: ALTITUDE Study of Aliskiren Terminated Early by Novartis

Patients in ALTITUDE were randomized to receive aliskiren or placebo in addition to an ACE inhibitor or an angiotensin receptor blocker (ARB).

FORBES: ALTITUDE Study of Aliskiren Terminated Early by Novartis

However, a triple therapy combination of a diuretic with an ACE inhibitor or ARB and an NSAID was associated with a 31% higher rate of kidney injury, particularly elevated in the first 30 days of treatment during which it was 82% higher.

FORBES: Acute Kidney Injury Associated With Dual Antihypertensive Therapy And NSAIDs