The drug certainly seems to work in at least some patients, although it is difficult to predict who will benefit.
There are suggestions that unemployment can even lead to cardiovascular disease, although it is difficult to prove that job loss causes heart damage.
Renal cell carcinoma accounts for approximately 2% of all cancers diagnosed in the UK, although it is difficult to treat, with a cure rate of about a third.
Although it is difficult to think what they might be talking about, we know Britain has now put up the idea that the new eastern countries could stop paying their bit of the rebate.
Similarly, failing to make a disclosure when there is fiduciary obligation to make a disclosure is something that can be clearly understood (although sometimes it is difficult to know when one has a fiduciary duty to another).
Some reports have suggested that certain food additives can cause behavioural changes in some children, although many experts agree it is difficult to come to firm conclusions from the research carried out so far.
Bove noted that although in many ways it is difficult to distinguish WaMu from the rest of its sector, it does hold the distinction of having a particularly tight link to subprime households, leaving it more vulnerable.
With Tony Blair's troops holding much of that old ground, it is certainly difficult to see the Tories moving to the overcrowded centre, although it is perfectly possible to see a leader in the mould of ex-minister Kenneth Clarke, if not the man himself, attempting to regain that one nation territory.
Surrounded by the plunging clifftop views, it is not difficult to imagine biblical kings and prophets panting their way up the slopes -- although it is more likely you will meet a battered truck laden with tomatoes grumbling up the steep inclines.
Although this is certainly possible, it is very difficult to gain serious traction in the Chinese marketplace by pursuing a purely export strategy, or by contract manufacturing and selling through sales agents.
"Although it is extremely difficult for any one government agency to influence the numbers and geographical spread of interpreters in England and Wales, steps are being taken across government to address the increasing demand for professional and suitably qualified interpreters, " said a spokeswoman.
She has since become an energetic player in the assembly, although, like the government, she is finding it difficult to respond to the complex challenges now confronting her country, our correspondent says.
Clearly the Web draws hours of use, although with multitasking it can be difficult to say what it is taking eyes and ears away from.
Although the negative attention that encompasses so many young stars is difficult to ignore, it is certainly not impossible, especially when there are plenty of youngsters out there truly making a difference.
Although the majority of the Japanese public opposes nuclear power, it is extremely difficult for the Economics Ministry to agree to the no-nuke pledge.
FORBES: Fukushima Slugfest -- Japan's New Nuclear Regulation Authority
Online peer reviews are notoriously unreliable, and although Amazon and other sites have made significant efforts to eliminate biased or untrustworthy reviews, it is still difficult to judge the quality of a book from consumer reviews alone.
FORBES: The Trouble With Finding Books Online - And A Few Solutions
Although the reopening went relatively smoothly, if confidence in the banking system does not properly recover, it is difficult to see how Uruguay can avoid a default on its foreign debt at some point.
And it should be harmful to domestic workers, although the evidence of large negative effects of immigration on domestic workers is difficult to find.
Because although Cisco has beaten earnings estimates in seven consecutive quarters (and counting), the company is finding it progressively more difficult to earn the respect of Wall Street.
FORBES: Cisco Spends $1.2 Billion For Respect, Was It Worth It
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