Human Genome last week announced favorable phase I clinical data about the safety and tolerability of a drug to fight anthrax infections.

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That leaves tiny differences in efficacy, and tolerability.

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Authorities should reconsider whether herbal medicines, as conventional drugs, need regulation and should be tested for safety, tolerability and efficacy for the benefit of our patients.

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The day before the opening today of the ASH conference in Atlanta, TG Therapeitics announced it has initiated a phase 1 and 2 clinical trials to evaluate the safety, tolerability and efficacy of its product, TG-1101, a novel third-generation anti-CD20 monoclonal antibody, in combination with Revilimid for patients with relapsed or refractory B-cell lymphoid malignancies who were previously treated with anti-CD20 antibody therapy.

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In this study, JUXTAPID was initiated at 5 mg daily and gradually escalated to doses of 10 mg, 20 mg, 40 mg, up to 60 mg, based on tolerability and acceptable liver enzymes levels.

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Unless differences in tolerability and side effects emerge, if both drugs are approved, doctors may look at the data and go with the Vertex drug first because its cure rates appear to be a few percentage points higher.

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