Drugs included angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs) and diuretics, with NSAIDs.

FORBES: Acute Kidney Injury Associated With Dual Antihypertensive Therapy And NSAIDs

Patients in ALTITUDE were randomized to receive aliskiren or placebo in addition to an ACE inhibitor or an angiotensin receptor blocker (ARB).

FORBES: ALTITUDE Study of Aliskiren Terminated Early by Novartis