Born in Yorkshire in 1925 into a working-class family, Prof Edwards served in the British army during World War II before returning home to study first agricultural sciences and then animal genetics.

BBC: Test-tube baby pioneer Sir Robert Edwards dies

Typically, these are motivated by a conspicuous success, a development program that was driven by the strength of beautiful molecular data, and the canonical example these days is PCSK9, a target which seems to feature an almost unprecedented alignment of human genetics, biomarker, and animal model data.

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