The goal was to jam the works by synthesizing an antisense strand of DNA to gum up the RNA section that codes for PKC-alpha.

FORBES: Antisense and Sensibility

Antisense drugs are named after one of DNA's two strands in its double-helix structure, which are known as sense and antisense.

FORBES: Antisense and Sensibility

An antisense drug, designed to look like the original DNA, could interrupt that process by binding to a complementary stretch of RNA and destroying it.

FORBES: Antisense and Sensibility

Antisense instead binds to the RNA messenger molecules that ferry genetic information from the DNA to the cell.

FORBES: Magazine Article

The terms sense and antisense were coined by Paul Zamecnik to show the complementary, double-strand nature of DNA. One strand consisted of alternating patterns of the four nucleotides that make up DNA adenine, cytosine, guanine and thymine and it could be read in order.

FORBES: Antisense and Sensibility

The terms sense and antisense were coined by Paul Zamecnik to show the complementary, double-strand nature of DNA. One strand consisted of alternating patterns of the four nucleotides that make up DNA adenine, cytosine, guanine and thymine and it could be read in order.

FORBES: Antisense and Sensibility