The third problem, that the results of clinical trials may be irrelevant to the real world, has several components.
However, the letter looks as though it refers to US retailers only so it would be irrelevant to the UK courts.
Even though it would be irrelevant to the estate case, Rebecca Stark Smith now hopes to get a court order exhuming bodies for DNA testing.
News that Hosni Mubarak, ousted last year after 30 years as despot, was near to death after a stroke in prison may be irrelevant to the outcome of the current power struggle.
Iraqis still are assumed to be irrelevant ciphers, malleable clay to be casually molded by an assertive American government.
FORBES: Death, Misery And Debt: Iraq's Unintended Conquest Of America
The Senate of the United States would be as irrelevant to that sort of world order as national parliaments in Europe have already become, thanks to the transfer of virtually all rulemaking authority to European Union bureaucrats in Brussels.
Many of his announcements were reheated (such as bringing aviation into Europe's emissions-trading scheme), modest (the climate-change levy, an industrial tax, will rise with inflation) or so speculative as to be irrelevant (a suggestion that the target for carbon cuts might be raised to 80% by 2050 from 60%).
And just like the payphone (sorry, Superman), the baseball dugout-bullpen phone connection will soon be irrelevant, thanks to new technology.
FORBES: MLB to Upgrade Bullpen, Dugout Phones with Multi-Million Dollar T-Mobile Deal
But to write it off as archaic or irrelevant would be to write off one of the most imaginative games ever designed.
Obama's rationale, that "our commitment to religious freedom must be unshakable, " seems utterly irrelevant to the issue of why the proposed Cordoba House should be constructed at Ground Zero.
The best way to become irrelevant is to be the same as everyone else.
That may turn out to be irrelevant but it is equally plausible that that matters.
An agency spokeswoman says any data found to be irrelevant will be deleted from the files.
NPR: Privacy Groups Sound Warning on Homeland Security Database
The tax year of the S corporation or partnership that actually produces the capital gain appears to be irrelevant.
FORBES: Business Owners Could Find Their Tax Deferral Backfiring
Mr Blair was clearly puzzled by what appeared to be an irrelevant question.
"What we're going to be doing is trying to make the embryonic stem cell irrelevant, " says Thomas St.
We should make it clear to our NATO allies that if they want to maintain an alliance that is increasingly irrelevant there are going to have to be some changes.
Years ago most cardiologists considered the inflammation idea to be "outlandishly irrelevant, a curiosity, " says Brigham's Libby, a pioneer in the field.
It might be irrelevant anyway - you've got to wait and see what the Welsh FA decide to do.
Det Insp Bobby Dow, the senior investigating officer, said: ''I appreciate that these people may think that they have nothing that could be of use to our inquiries, but they were in the area at this particular time and they may have seen something, however irrelevant they believe it to be, that could help us in our efforts to find Mr McMurchie's killer.
BBC: John McMurchie murder: Police in Dundee seek two witnesses
But it would be a mistake to write them off as irrelevant to the rest of the world.
By a vote of 90 to 7, the Senate rejected his argument that he should not be convicted because filing a false return was irrelevant to his performance as a judge.
Usually this is because manufacturers themselves have a schizophrenic attitude: they yell about it when their transistors are nice and small, but then treat the whole topic as irrelevant when their transistors happen to be lumpier than the competition's.
ENGADGET: Primed: why nanometers matter (and why they often don't)
Coke, however, feels that labor-based fees are irrelevant, and that compensation should be tied solely to business results.
So even if Google and Apple do to Smart TV what they did to Smartphones, Roku would hardly be irrelevant.
FORBES: Anthony Wood: How Roku Prospers In An Apple-Google TV Invasion
However, as the RMB becomes one of the big boys in the global forex market from being irrelevant a decade ago, investors would be wise to remember that what goes up, can come down.
In fact, I would expect a person in my network to be honest with me, as I have with my network, to inform when skills are becoming irrelevant.
"It's irrelevant as to how this letter came to be, " Mr. Liu said.
That sounds as if Mr Blair is hoping that there will be enough agreement between employers and unions to make legislation irrelevant.
But such checks will now be largely irrelevant, since the police will have no grounds to detain any offenders they catch in this way unless the federal government asks them to.
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