ImClone Systems ' breakthrough colon cancer drug Erbitux has become a billion-dollar best seller as a one-size-fits-all drug for patients who have failed treatment with chemotherapy.

FORBES: ImClone's Gene Test Battle

As a consequence, when everything fell off a cliff the following year the book went on to become something of a minor best-seller.

FORBES: The Complication of Leadership

The goal: to create a drug that would prevent heart attacks and become a massive seller, potentially replacing Lipitor, the world's best-selling medicine, when it loses patent protection as early as 2010.

FORBES