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The 38-year-old Romanian picked up the gold in Beijing but has never finished the London Marathon higher than the third place she gained in 2007.
BBC: Radcliffe set for London return
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Radcliffe's return to form in New York and in the Great South Run came after a disappointing display at the Beijing Olympics where she finished 23rd in the Marathon.
BBC: Radcliffe set for London return
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Radcliffe, who finished 23rd in the marathon at the Olympics after her build-up to Beijing was hampered by a stress fracture of her left thigh, showed no signs of fatigue.
BBC: Superb Radcliffe wins Great South
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The jury is still out on whether Beijing will manage to produce air sufficiently breathable for runners safely to complete a marathon.
ECONOMIST: The Beijing Olympics
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German runner Mikitenko missed Beijing through injury but followed up her return with victory in September's Berlin Marathon and last month was crowned the 2007-08 World Marathon Majors champion.
BBC: Radcliffe set for London return