Levels of the beta amyloid protein naturally rise and fall over 24 hours in both mice and people.
Beta amyloid is a protein fragment that collects in clumps inside the brains of Alzheimer's patients.
To be specific, Merck (MRK) will test a beta-amyloid precursor protein site-cleaving enzyme, or BACE, inhibitor, which the drugmaker notes is the first drug with this type of mechanism to advance to this stage of clinical research.
The main anatomical symptoms of Alzheimer's are the growth in the brain of plaques of a protein called beta amyloid, and tangles inside cells of a second protein called tau.
Most researchers are focusing on blocking the formation of amyloid-beta protein or removing it from the brain, either before or after deposits are formed.
Harvard University researchers conducted experiments on mice using oligomers, a soluble form of amyloid-beta protein, which is the key compound in brain plaque and a hallmark of Alzheimer's.
It binds not just to tau, but also to another protein called beta amyloid, which is commonly seen in Alzheimer's disease patients.
AN-1792 was a vaccine that immunized patients against a protein called beta amyloid, which is the main component of the plaques that destroy the brain in Alzheimer's disease.
The dominant explanation of Alzheimer's disease contends that the massive brain cell death is due to the buildup of plaques containing a protein called beta amyloid built up in the brain.
The physical manifestations of the disease that Alois Alzheimer noticed in 1906 are sticky plaques of one type of protein, now known as beta-amyloid, and nerve-cell-engulfing tangles of a second type, called tau protein.
Most scientists believe that Alzheimer's disease is linked to a protein called beta-amyloid.
It trained the patient's own immune system to attack a protein called beta-amyloid that many scientists believe is implicated in Alzheimer's.
They will be widely viewed as a referendum on the prevailing theory in Alzheimer's drug development, which focuses on sticky clumps of protein known as beta amyloid that build up in the brain.
Other researchers had identified several related protein fragments, called beta-amyloid, inside the amyloid plaques, but they didn't know which proteins were the bad ones.
Other researchers had identified several related protein fragments, called beta-amyloids, inside the amyloid plaques, but they didn't know which proteins were the bad ones.
Most researchers still believe beta-amyloid is the culprit, but the idea that free-floating protein molecules, rather than the proteins in the plaques, are to blame is gaining ground.
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