The head of the IMF was a heavyweight, a big beast who has been at the heart of international efforts to prevent a global recession.
"I may not be that big but I'm a giant at heart and I think that is the most important thing, " he says.
So it is strange that agriculture should now lie at the heart of two big global projects of the next year or so: the Doha round of trade talks and the eastward expansion of the European Union.
Clearly there are serious problems, but they hardly look big enough to set off a crisis at the heart of the global financial system.
There's a big difference, though, and it lies at the heart of Rosen's success.
In the final analysis, despite our big brains and eons of evolution we remain, at heart, simple creatures of habit.
Moreover, he says, the drug seems to work best in patients with the cholesterol-related genetic disorder, which is unexpected but could be a big help for these patients, who are at risk for heart attacks and strokes.
But was it wise of Mr Obama to put such a big thing, such a complicated thing, at the very heart of his presidency in his very first year, in the middle of America's worst recession for decades?
After all, fringe benefits are at the heart of union deal-making with big business.
At heart, this is a debate over how big a role the federal government should play in steering the nation's economy and deciding how its spoils are shared.
Prices are also 9% lower than at the big hospitals in town, says Jon Soderholm, the heart hospital's president. (Sanford says it's impossible to accurately compare prices.) The only thing that the heart hospital is guilty of, in Soderholm's mind, is having a 70% market share.
Or, for more thoroughly familiar fare, end your child-friendly Delhi day in at the United Coffee House for a comforting bowl of pasta marinara, the All American Diner for a pretty decent hotdog or The Kitchen at the heart of the relaxed Khan Market, for a big, familiar plate of fish and chips before bedtime.
In a bewildering result, an experimental drug aimed at reducing inflammation in the arteries failed in a big clinical trial but prevented heart attacks, strokes and deaths, according to a press release from the drug's maker.
Doctors who treat heart attacks are excited at having a new cheap option that can take a big chunk out of patients' cholesterol.
Topol, chief academic officer at Scripps Health, says he tried to get Schering and Merck to start a big heart-attack-prevention trial of Vytorin four years ago.
Bruno Iksil, the trader at the heart of the incident, was dubbed the London Whale because the positions taken were big enough to move markets.
But even toward the end of his tenure at Lederle, big pharmaceutical companies were starting to pare back on antibiotics, opting for more lucrative cancer and heart drugs.
Since corporate change has to start from the top, a lack of biotech-savvy corporate governance may be at the heart of the issue: the reality is there are few if any biotech voices in Big Pharma boardrooms.
FORBES: Change Starts at the Top: Imperative to Bring Biotech Voices to Pharma Boardrooms
" "He related to the people from his heart, he wasn't just looking at the teleprompter, he was coming through in a big way.
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