These agents fall into several classes that include statins, fibric acid derivatives, bile acid sequestrants, nicotinic acid (also known as niacin) and the cholesterol absorption inhibitors.

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They also ignore decades of prior clinical end point data, such as NIH CPPT and POSCH on bile acid sequestration, that formed the basis for NCEP ATP I prior to any statin clinical outcomes.

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In LRC-CPPT, patients on cholestyramine, a bile acid sequestrant resin, had 20% lower LDL as compared to an 8% drop on placebo and, after seven years, had a 24% reduction in CV deaths versus placebo.

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"What calcium appears to do is help to bind both fatty acid and bile acid within the colon to prevent them from interacting with the colon lining and therefore reducing the irritant effect of these substances upon the colon, " said lead researcher Dr. Peter Holt of St.

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