Two patients with especially advanced ALL experienced what Dr. Brentjens termed a "shake and bake response" significant fever and a drop in blood pressure that resulted in their admission to intensive care.

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They justify it by saying that feedback doesn't apply to them they aren't as likely to die before 60 as other people, for instance, because they have grandparents who lived into their 90s, or because they are avid gym goers with low blood pressure.

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