Rebecca Soni, a surprise gold medalist in Beijing, is a favorite in the 100- and 200-meter breaststroke.
Brenton Rickard, Australia's 100m breaststroke world champion, looked strangely off the pace as he narrowly crept through his semi-final.
BBC: First Commonwealth Games golds for England and Scotland
Scotland's Sean Fraser won Para S8 100m freestyle silver behind Australia's Ben Austin, while England's Kate Haywood earned 100m breaststroke bronze.
From the improving Japanese team, Kosuke Kitajima will try to repeat his double-gold performance in Beijing in the 100- and 200-meter breaststroke.
There were also British records for Dave Ellis (S13 100m butterfly), Claire Cashmore (S8 50m and 100m breaststroke) and Anthony Stephens (S5 100m freestyle).
Japan meanwhile were celebrating after landing their first Olympic swimming title for 12 years when double world champion Kosuke Kitajima won the men's 100m breaststroke.
Grimsby's Haywood, 23, won 100m breaststroke bronze as Leisel Jones took gold ahead of team-mate Samantha Marshall, despite a goggle crisis in the immediate build-up to her final.
Lithuanian Ruta Meilutyte won her country's first swimming medal ever as an independent nation, winning gold in the final medal event of the night, the women's 100-meter breaststroke.
Kirsty Balfour was in record-breaking form as she booked her place in Montreal with victory in the 100m breaststroke in a Scottish record time of one minute 08.66 secs.
BBC: SPORT | Other Sport | Swimming | Gibson earns place in Montreal
Ireland's Michael Williamson clocked 1:02.23 in the morning heats of the 100m breaststroke which was a personal best and he will look forward to joining Bree in Sunday's longer event.
BBC: SPORT | Northern Ireland | Bree unable to repeat heroics
He hauled it in, slid himself back via something like a reverse breaststroke, got to his knees, stood, retreated a few steps, and was once again fifteen feet away and safe.
Kate Haywood took bronze for England in the women's 50m breaststroke, while Stephanie Millward added another English bronze in the Para sport 50m freestyle S9, won by South Africa's Natalie du Toit.
BBC: First Commonwealth Games golds for England and Scotland
The swimmer, Mohammad Alirezaei, did not compete in the men's 100-meter breaststroke heat Saturday because of illness and not for any other reason, a spokesman for the Iranian Embassy in Beijing told CNN.
South Africa's Cameron van der Burgh put in the fastest 50m breaststroke time in the world this year, a Commonwealth Games record of 27.18 seconds, to win gold and complete a 50m-100m double.
Success for Australia came with a one-two in the women's 50m breaststroke final, Leiston Pickett winning in 30.84 ahead of Leisel Jones in 31.10, with Haywood a further seven hundredths of a second behind.
BBC: First Commonwealth Games golds for England and Scotland
Of the international contingent in Sheffield, German swimmer Kirsten Bruhn was in top form, achieving world records in the SB5 50m and 100m breaststroke and a new European best in the S7 100m backstroke.
Thursday's success for Scottish Olympians followed Lossiemouth rower Heather Stanning winning gold alongside Helen Glover in the women's pairs on Wednesday, the same day as Glasgow-born Michael Jamieson won silver in swimming's 200m breaststroke final.
Swimming's micro-scandal came last week after South African swimmer Cameron van der Burgh was asked by reporters about an underwater video that showed him using three underwater "dolphin" kicks at the start of a breaststroke race.
"I think the experience I have gained from the previous Games will help this year, " said Kindred, who won gold in the SM6 200 IM and SB7 100m breaststroke in Athens and who will be appearing in his fourth Paralympics in Beijing.
London (CNN) -- Young stars shone at the Olympic pool Monday as Yannick Agnel of France won his second gold medal of the London Games, American teen sensation Missy Franklin won her first and a 15-year-old Lithuanian stunned the women's 100-meter breaststroke field.
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