The goal: a drug against osteoporosis, the brittle-bone disease that afflicts 25 million older Americans, mostly women.
But far worse, it melted at high temperatures and became brittle at low ones.
Set against successful replanting of low-lying bushes, the dead and brittle trees are strangely beautiful.
The resulting aerogel blanket was flexible rather than brittle, which solved the handling problem.
Thirty years ago some contractors used brittle PVC pipes that burst when they froze.
"Technology is brittle, " said Jaime Punishill, an analyst at Forrester Research Inc. in Cambridge, Mass.
Ms Cutland highlighted the case of Casey Brittle, who was murdered by her former partner.
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Bone mineral density may be compromised by tobacco, making bones more brittle and break-prone.
Natural-gas pipelines cannot be used because hydrogen makes the steel tubing brittle and attacks the welds.
For dessert, the Milk and Honey shortbread, brittle and ice (an Eleven Madison classic) was great.
Annette Bening may also be considered for Oscar gold for her portrayal as his brittle wife Carolyn.
As brittle and imperious as Bishop could be, she also could be a warm and considerate friend.
But Motorola is also exhausting them, as its patent legacy looks more brittle than Google anticipated.
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The discussion touched on data which suggested that the O-rings might be more brittle at lower temperatures.
"It's a certain kind of sound that is a bit brittle and a bit nasal, " she said.
Have them replaced whenever they appear cracked, brittle, frayed, become loose or show signs of excessive wear.
Theron's brittle executive officer is just too close to caricature, and she's not the only one either.
It has many brittle areas, such as management of its name space, compared to the best enterprise software.
But there are rules that can make it easier to cope with the failures of such brittle technologies.
As a fighting force, European countries will prove a brittle cane on which to lean in operations abroad.
While LCD screens have made major strides, they have two inherent problems: They gulp energy and are extremely brittle.
Other studies have suggested statins can protect against Alzheimer's and even brittle bones.
In die-casting, the alloys tend to be brittle and have poor wear resistance.
Or it could go the way of Turkey, and evolve into something less brittle and happier for all concerned.
They all contain whites, and yolks and are enveloped in thin, brittle shells.
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Kenya is east Africa's most dynamic country but it remains a brittle construction left behind by British colonial rulers.
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Brittle-looking birch trees with black marks on their white bark, and some small, untidy evergreens, rolled up like sleepy bears.
"Dodd-Frank has made the system more brittle and has shaped the next crisis in a very negative way, " he warns.
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"A lot of security systems are hard and brittle, " says Robert Baldwin, head of the security firm Plus Five Consulting.
With the tailgate open, the breath-taking beauty of snowbound Afghanistan unfolded beneath us, the landscape stark, brittle and largely empty.
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