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"These findings provide the first proof in man that aspirin prevents distant cancer metastasis, " the second study's authors concluded.
WSJ: Studies Find New Evidence Aspirin May Prevent Cancer
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They found that, with a mean follow-up of 6.5 years, allocation to aspirin reduced risk of cancer with distant metastasis by 36%, risk of adencarcioma (common solid cancers including colon, lung, and prostate cancers) by 46%, and of other solid cancers (eg bladder, kidney) by 18%.
FORBES: Meta-Analysis Adds New Evidence For Cancer Benefits Of Daily Aspirin
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The authors did this comparison because while randomised trials of aspirin could clearly establish the risk of colorectal cancer, several other solid cancers, and of metastasis, these trials lacked the statistical power to establish effects on less common cancers and on cancers in women.
FORBES: Meta-Analysis Adds New Evidence For Cancer Benefits Of Daily Aspirin
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Aspirin reduced death due to cancer in patients who developed adenocarcinoma (especially those without metastasis at diagnosis, by around half).
FORBES: Meta-Analysis Adds New Evidence For Cancer Benefits Of Daily Aspirin
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It is consistent with Gompertz's growth curves and ties together two essential features of cancer that researchers had long considered separate--cell growth and metastasis.
FORBES: Magazine Article
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Moreover, there were significant differences between mutations in the original tumor and the site of metastasis, suggesting the need for additional biopsies as a patient's cancer progresses.
WSJ: 'Personalized Medicine' Hits a Bump
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The researchers also found that aspirin reduced the risk of adenocarcinoma with metastasis at initial diagnosis by almost a third (31%), and risk of metastasis on subsequent follow-up in patients without metastasis initially (by 55%), particularly in patients with colorectal cancer(by 74%), and in patients who remained on trial treatment up to or after diagnosis (by 69%).
FORBES: Meta-Analysis Adds New Evidence For Cancer Benefits Of Daily Aspirin
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By studying whether Abraxane works in pancreatic cancer, where many cells are churning out Sparc, he will be able to help solve the mystery of metastasis.
FORBES: Patrick Soon-Shiong and one of cancer's biggest riddles.