Also in the same issue, the journal is publishing results of the colon cancer prevention study that led Merck (nyse: MRK - news - people ) to withdraw Vioxx last fall.

FORBES: More Pain For Pfizer

In another recent cancer prevention study that found no excess heart risk in Celebrex users, patients only took Celebrex once per day, not twice as in the NCI study, potentially reducing any damaging effects to the heart from Cox-2 inhibition.

FORBES: More Pain For Pfizer

Now, however, there are data showing some sign of heart risk for every Cox-2 inhibitor ever approved in the U.S. Vioxx doubled the risk of heart attack and stroke in one cancer prevention study, and now the same is true for Celebrex.

FORBES: Pfizer's Heart Attack

"Given this new data, " Kim said, "it is not clear that the cardiovascular risk seen in Approve makes Vioxx unique in the class of similar drugs marketed in the U.S." Approve is the cancer-prevention study that turned up the heart risk for Vioxx.

FORBES: Could Vioxx Come Back?

"I would not recommend that women use NSAIDs for breast cancer prevention, " says study author Bahi Takkouche, M.

CNN: Study: Aspirin, ibuprofen may cut breast cancer risk

That study suggested that the cancer prevention benefits outweighed the risks of internal bleeding.

BBC: Aspirin - risks and benefits

This study, part of a long-running skin-cancer-prevention trial, covered 903 adults younger than 55 living in Nambour, Australia, near the country's Sunshine Coast.

WSJ: Sunscreen Each Day Stops Wrinkles

"Compliance has not been enforced so I'm not surprised people don't understand the risks, " said Meg Watson, study author and epidemiologist at the Centers for Disease Control and Prevention's Division of Cancer Prevention and Control.

CNN: Indoor tanning industry under scrutiny