The Spanish clay court specialist won 6-4 3-6 6-1 against third seed Stanislas Wawrinka of Switzerland.
Wozniacki took the defeat in her stride as she moves on to the clay court season.
Nadal has pulled out of this week's Mercedes Cup clay court event in Stuttgart, citing a knee problem.
Govortsova put out former French Open champion Francesca Schiavone in her opening match at the clay court event.
But the Russia superstar is just proud to be back with the clay court grand slam under her belt.
Put Nadal on a wet clay court with Djokovic or even Gulbis, Roger Federer, or Tomas Berdych and he could suffer.
"I think he's favorite, he's the greatest clay court player in history, " was the verdict of the world number 12.
Elsewhere, John Isner won his career title after overcoming Spain's Nicolas Almagro in the final of the U.S. Clay Court Championship.
Nadal won the final tournament of his early season 'clay court swing' in Mexico at the weekend and Federer took note.
CNN: Federer: Good to have Rafa back as Indian Wells clash looms
He will now look to get fit ahead of the clay court season and his defense of the French Open title.
Murray moved to 10th in the world rankings on Monday after Tommy Haas failed to reach the US Clay Court Championships semi-finals.
But tennis is so different these days that a slow, muddy clay court works to Nadal's disadvantage, as last year's men's final showed.
The Russian top seed was a late entry to the clay court tournament but ended the week with her second title of the year.
In the Barcelona Open, Italy's seventh seed Sara Errani shocked third seed Dominika Cibulkova of Slovakia 6-2 6-2 to win the clay court event.
Nadal dominated David Ferrer 7-6 6-0 in the earlier semifinal to go into his seventh final at the clay court tournament in the Italian capital.
The two favorites for the clay court season are so good that they're going to make it more difficult for either of them to win.
An example court pace rating for each surface may be 23 for a clay court, 35 for a hard court and 46 for a grass court.
Meanwhile, on the WTA Tour, China's Li Na reached the quarterfinals of the Stuttgart tournament with a straight sets win in her first match of the clay court season.
The clay court season now looks towards the start of the Madrid Open on Monday, which has caused controversy over its use of blue clay for the first time.
The crowd at the Foro Italico were treated to a clay court exhibition, particularly in the first set as the 26-year-old Spaniard broke Berdych a second time to rub it in.
"I had a great week of practice and I was ready to go, " said the big-serving Isner, who will be the second seed at this week's U.S. Men's Clay Court Championship.
The venue for Great Britain's 7-9 February Davis Cup tie against Australia is yet to be confirmed, but it is expected to be held on a specially-constructed clay court in Sydney.
"It's going to be a lot of fun ... to see how I can adjust to clay court in indoor conditions, playing away Davis Cup, which is always tricky, " he said.
"I'm not a clay court specialist that's going to stand 10 feet behind the baseline and retrieve balls back, " said Sharapova, who needs a win in Paris to complete a career grand slam.
The 34-year-old Haas received a wild card to make his first appearance at the clay court tournament in five years and repaid the compliment with a 6-1 6-4 victory in just 59 minutes.
CNN: Haas rolls back the years to stun top seed Tsonga in Munich
The United States, missing both the Williams sisters, were still too good for France as they wrapped up a 4-1 win on an indoor clay court at the Stade Couvert Regional de Lievin.
Nadal has made the title his own at the distinctive clay court tournament overlooking the Mediterranean and was clinching his 20th in a Masters 1000 tournament, the first man to reach that landmark.
With the clay court season about to kick off, Djokovic is keen not to take any unnecessary risks ahead of the Masters events in Madrid and Rome before going into the French Open next month.
Venus, the fourth seed at the clay court tournament, was broken early and lost the opener to the 15th-seeded Italian, but recovered to win the next two sets easily for a 3-6 6-1 6-2 win.
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