Although there's a rough total of reported cases, we don't know how many there have really been, and how often these are serious, because we have little idea how many people have sub-clinical symptoms.
First, of course, what are the clinical signs and symptoms of these diseases because few of us have ever seen cases?
Dr Urquhart, who was employed by the Torbay Health Authority and the South Devon Healthcare NHS Trust, is accused of failing to recall three patients for assessment who had "significant clinical signs or symptoms".
Older guidelines assigned a grade to concussion severity from 1-3, based on degree of symptoms and other clinical features.
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The drug has previously been shown to improve jet lag symptoms in a clinical trial, according to results published last year in the Lancet.
Secondary endpoints including time to clinical worsening and changes in other symptoms also did not differ significantly from a placebo.
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Eli Meltzer , an allergist at the University of California at San Diego, led the clinical trials that tested Singulair against allergy symptoms.
In clinical trials, Januvia caused cold-like symptoms and diarrhea in some patients.
Earlier this month, the FDA rejected Wyeth's Pristiq, an antidepressant that was being tested for menopausal symptoms, saying it wants additional clinical trials on the drug's heart and liver side effects.
Another new drug, tolvaptan, from Japanese drug firm Otsuka, improved the symptoms of heart failure patients in a clinical trial presented at ACC.
The most common adverse reactions in the clinical trial included injection site reactions, flu-like symptoms, nausea, headache and elevations in liver enzymes (serum transaminases).
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The researchers defined minor depression as milder than clinical depression but lasting at least two weeks and including symptoms such as feeling down, losing interest in activities, sleeping problems and poor concentration.
Some of the ASAM symptoms of behavioral addiction can potentially be defined as an RRBI in clinical practice.
The team is now conducting clinical trials to see if giving the sunshine vitamin to patients could ease their symptoms.
After the shootings at Virginia Tech that left 32 students dead in April 2007, Jones, a clinical psychologist, was one of the counselors who went into classes to discuss the symptoms of depression, acute stress disorder and PTSD.
You can find this approach in clinical practice when patients are processed in 15-minute blocks during which a prescriber hunts for symptoms and uses a loosely crafted, often-times commercially driven, algorithm to pick which medication(s) to prescribe.
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To Krumholz, this is part of a larger tapestry of unexpected clinical trial results that should make doctors, patients and regulators demand more hard information about whether drugs reduce symptoms or prevent problems like heart attacks and deaths.
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