Dr Howe said that the test had never been clinically proven to be better than the alternatives.

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It "is clinically proven to help protect skin" from moderate sun exposure, boasts its website, citing an unpublished 56-patient study.

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It defies common sense that a 15-minute treatment is going to eliminate or even minimize them, no matter how "clinically proven" the ingredients employed to reduce wrinkles, puffiness and dark circles.

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There is not as of yet a clinically proven link between plaque measured with IVUS and heart attacks, and IVUS can only be done in patients whose cardiovascular disease is so severe that they need a catheter for another reason.

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But when Mr. Papadellis said in a recent interview that one of his first tweets would mention drinking cranberry juice before eating sushi to prevent food poisoning, his director of communications, Cindy Taccini, quickly nixed the plan, noting that the claim hadn't been clinically proven.

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From Phase II studies as well as the Phase III Oral Solo trial (presented at the ACR last November), the agent has proven to be clinically potent and rapidly effective.

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