The new class of drugs, called Cyclooxygenase-2 or Cox-2 inhibitors, are no better at easing swelling or numbing hurt.

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Cox-2 inhibitors, developed with much hype in the mid-1990s, block an enzyme called cyclooxygenase-2, in so doing shutting off a wide-reaching cascade of biochemical signals that take the form of fats called prostaglandins.

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