Marlon Harewood headed in a fourth as Bolton rued earlier missed chances by Heidar Helguson and Danny Guthrie.
Martins almost ended the stalemate 10 minutes before the interval when Danny Guthrie's persistence created an opening.
Youngsters Lee Peltier and Danny Guthrie were given European debuts and Jerzy Dudek was recalled in goal.
The 25-year-old was injured after a tackle by Newcastle's Danny Guthrie in Hull's 2-1 victory at St James' Park.
The tactic almost paid off but both Danny Guthrie and Enrique's fizzed balls across the six-yard area eluded their team-mates.
Danny Guthrie saw red for a second yellow card after the break, allowing the hosts to ease to a comfortable win.
Jonas Gutierrez opened the scoring with a strike that deflected off Ian Evatt before Andy Carroll headed home a free-kick from Danny Guthrie.
Forest kept up the pressure, but Danny Guthrie, making his 100th club appearance, came close to putting the home side in front from a set-piece.
Reading put Bolton under intense pressure after the break, and on 50 minutes a corner swung in and the ball was cleared off the line by Danny Guthrie.
Lee Cattermole was biting hard into tackles and Joey Barton had to be replaced by Danny Guthrie after a heavy challenge from the Wigan midfielder in the 15th minute.
Newcastle have not been helped by a series of injuries and suspensions, but they will be boosted by the return of Danny Guthrie, who has completed his three-match ban.
Keegan then introduced Danny Guthrie as a half-time substitute and the young midfielder, recently signed from Liverpool, did not take long to make an impact on his new team.
Danny Guthrie forced Cech into an early save, while the Czech keeper was forced into action again to deny Davies after the stand-in skipper ended a driving run with a low strike.
Carroll should have extended his team's lead after Danny Guthrie picked him out at the far post with a deft cross but the unmarked striker found the side netting with his header.
Danny Guthrie played a ball over the top of the Gunners defence to release Nile Ranger and, after he stumbled past the challenge of onrushing keeper Wojciech Szczesny, his shot was blocked by Koscielny.
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