Nedum Onuoha, Danny Welbeck and Asamoah Gyan were all injured in the Black Cats' 2-0 home defeat by Blackpool.
In England's win over Sweden, Danny Welbeck and Andy Carroll completed just 58% of their 80 combined pass attempts.
England striker Danny Welbeck's sumptuous late winner settled a topsy-turvy match as Sweden were sent crashing out of Euro 2012.
Dimitar Berbatov volleyed home to extend the lead before 17-year-old Danny Welbeck marked his Premier League debut with a stunning strike.
Capello also fended off the suggestion that Danny Welbeck was handed his England debut to keep him out of Ghana's clutches.
Asamoah Gyan, Darren Bent and Danny Welbeck all squandered good openings and visiting goalkeeper Richard Kingson made a number of excellent stops.
The 25-year-old is currently the club's only fit forward following Darren Bent's move to Aston Villa, and injury to Danny Welbeck and Fraizer Campbell.
With nine minutes remaining, Arshavin allowed United's Valencia to breeze past him and surge into the penalty area, where he laid on the winning goal for Danny Welbeck.
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Owen will add extra experience to an attack that still boasts plenty of established talent in Wayne Rooney and Dimitar Berbatov, plus youngsters Danny Welbeck and Federico Macheda.
But for all the home side's pressure, clear-cut openings were at a premium - although substitute Danny Welbeck was guilty of blazing over after being set up by Bent.
It might even have been worse for Arsenal as Sunderland, who had lost each of their previous four matches, came close to snatching a late winner through Danny Welbeck.
And his replacement, Russian Andrei Arshavin, failed to close down Valencia as he got into the area late in the game to tee up England striker Danny Welbeck for the winner.
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Meanwhile, the Chelsea fan who allegedly made racist gestures at United's Danny Welbeck during Wednesday's League Cup tie has been named as 28-year-old Gavin Kirkham from the county of Hertfordshire, north of London.
However Ferguson is not confident young Manchester United striker Danny Welbeck, who made eight appearances for Preston on loan last season before returning to Old Trafford with a knee injury, will agree to another loan deal at Deepdale.
Dimitar Berbatov had given United a 30th-minute lead in Toronto and, although Georgios Samaras equalised from the penalty spot after an hour, late goals from Danny Welbeck and Tom Cleverley gave the English side victory in the friendly.
Theo Walcott, a substitute, blasted in an equalizer with his first touch since coming on and then crossed for Danny Welbeck, the striker, to score one of the goals of the tournament, a twisting back-heel flick into the corner of the goal.
But with the deal now dead in the water he will have to look elsewhere as he seeks to cover Bent and Danny Welbeck who is out for eight weeks after exploratory knee surgery, with Fraizer Campbell also a long-term absentee.
Ronaldo had received a warm welcome from home fans on his return to Old Trafford, while Ferguson sprang a surprise with the omission of Rooney, giving starts to 39-year-old Ryan Giggs, playing his 1, 000th game for club and country, Nani and Danny Welbeck.
The one moment they relied on a bit of luck was when Asamoah Gyan and Danny Welbeck combined beautifully down the left before Welbeck swung in a delicious ball across the area, which Kieran Richardson only just failed to get a toe to.
United were denied a penalty by Mike Riley in last week's FA Cup semi-final defeat to Everton when Danny Welbeck appeared to be felled by Phil Jagielka, a decision that United boss Sir Alex Ferguson was quick to highlight in discussing Webb's decision.
In addition to the defensive problems -- first-choice goalkeeper Edwin Van der Sar is also missing -- Ferguson has taken the option of leaving strikers Wayne Rooney and Dimitar Berbatov at home, meaning Michael Owen and Danny Welbeck are the only forwards in his 19-man squad.
Bruce has fellow strikers Asamoah Gyan and on-loan Danny Welbeck, who is currently injured, to call on and, although they have eased the reliance on Bent with 14 goals between them this season, they will have to prove they have the consistency to ease the impact of his departure.
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