Second seed and defending champion Yanina Wickmayer demolished Simona Halep of Romania 6-0 6-2.
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"You can't lie about it the greens are shaky, " defending champion Rickie Fowler said Wednesday.
She held off Great Britain's Christine Ohuruogu, the defending champion, to win in 49.55 seconds.
The taint of drugs has already robbed this year's race of its defending champion.
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Second seed Mikhail Youzhny was also beaten, losing 6-2 6-0 to defending champion Jonas Bjorkman .
Provisional world number one Ken Doherty and defending champion Ding Junhui edged ahead in their matches.
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Ironically, defending champion Mickelson missed 12 chances to replace Woods as number one this year.
Defending champion Phil Mickelson was six shots back alongside PGA champion Keegan Bradley and Ryan Palmer.
The defending champion Cardinals (27-5) harassed Villanova into 25 turnovers that led to 27 points.
Defending champion Murphy has suffered some agonising final-frame defeats this season but came through this time.
Defending champion Silvia Cavalleri carded a 69 on Sunday to finish tied for 29th place.
Defending champion Janeth Jepkosgei of Kenya took the silver and Jennifer Meadows of Britain claimed bronze.
Defending champion Lee Westwood shared third place with Alvaro Quiros to remain as world number one.
Defending champion Djokovic secured his place in the semi-finals by beating Gilles Simon 6-3 6-2.
Defending champion Stephen Lee is also out after going down 5-2 to Nigel Bond.
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Defending champion and top seed Victoria Azarenka was made to work harder on Saturday.
Defending champion Scott Martin of Australia is attempting a shot put and discus double.
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The defending champion saves it with a smash that wrong-foots Murray, who winces afterwards.
The final road game of this stretch being a road contest against the defending champion Miami Heat.
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The defending champion, who is president of the ATP Player Council, said a strike makes no sense.
"It's definitely good to be back, " said Venus, seeded second behind her sister Serena, the defending champion.
The 30-year-old from Sheffield had also beaten defending champion and five-time winner Amr Shabana in the semi-finals.
Defending champion Janeth Jepkosgei was second, a massive 2.45 seconds adrift, with Britain's Jenny Meadows taking bronze.
Also riding will be Scotland's David Millar along with Australian Mathew Hayman, who is the defending champion.
The Irishwoman outsprinted defending champion Berhane Adere to win the 10km race in 32 minutes 12 seconds.
In the women's section, defending champion Maria Sharapova eased to a 6-2 6-2 win over Spain's Garbine Muguruza.
Indiana now advances to the Eastern Conference Finals, where they'll be underdogs against the defending champion Miami Heat.
The Kenyan crossed the line ahead of Ireland's Martin Fagan and his compatriot and defending champion Luke Kibet.
Defending champion Bubba Watson made the cut by the skin of his teeth after carding a one-over 73.
Russia's Ivan Skobrev was promoted to silver and the Netherlands' defending champion Bob de Jong won the bronze.
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