Quarantined populations have been established but efforts to find a cure have been depressingly fruitless.
Depressingly, treatments do not seem to be advancing as they have done with adult cancer.
The age-old pay gap between men and women is, depressingly, as strong an institution as ever.
But the texture of Theresa's improbable flirtation with this septuagenarian rake is depressingly innocent.
Depressingly for football fans, it is not going to be easy or quick to change.
The current crisis is a sort of super-sized, IMAX version of a depressingly familiar horror film.
Depressingly, today it is less apparent that Netanyahu has in fact abandoned their legacy of defeat.
There is no debate going on and the result will be one-sided and depressingly divisive.
But unlike Americans, Britons like their reality to be depressingly, and sometimes tediously, real.
The report said despite the clear consensus over what diabetes patients needed, performance had been "depressingly poor".
These vested interests always complain, with depressingly predictable outrage, about every change to a system which is failing.
Yet against that depressingly familiar backdrop, some fundamental numbers are moving in the right direction (see article).
How we got here is depressingly familiar in an age of financial mis-engineering.
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Depressingly, the first act of the new Congress government in Andhra Pradesh was to restore free electricity to some farmers.
It felt as if a profoundly important issue had been touched - but one which was depressingly far from being resolved.
While the PC has gotten easier, newer technologies, such as wireless home networking, are as depressingly complicated as computers once were.
For those familiar with China's banking reforms, such setbacks are depressingly familiar.
Stalemate, gridlock, and lack of public confidence: it all sounds depressingly familiar.
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Policy entrepreneurs piggyback on zombies to capture attention, but they too often overlook a key element of zombie stories: They are relentlessly, depressingly apocalyptic.
This feel-good comedy, directed by Ron Underwood from a script by Lowell Ganz and Babaloo Mandel, is a depressingly efficient piece of Hollywood product.
Begin with the depressingly long list of reasons to be pessimistic.
And the proportion number of young people in custody who had grown up in the care system - 30% - remained "depressingly high", said the report.
But the Guardian's US newsblog points out Mayer is not the first female chief executive with a family, though it says "the number is depressingly low".
The opening exchanges of the second half followed a depressingly similar trend to the first half, although Portsmouth's midfield began to impose more authority against their better-paid opponents.
The years may pass, but human motives remain depressingly unchanged.
Despite a century of accumulated evidence for anthropological climate change, we remain depressingly far away from the sort of global coordinated action which is needed to tackle the problem.
Mixing up the difference between the country's total accumulated debts and one year's additional borrowing (the deficit) is something politicians - and, yes, even senior BBC broadcasters - do depressingly often.
Although"Attention All Passengers" addresses the industry's finances, the book does not offer the sort of extended discussion of the complex economic fundamentals that explain the depressingly relentless decline in customer service.
Depressingly little thought has been given to these questions.
Their chances of actually doing so are depressingly slim.
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