Quarantined populations have been established but efforts to find a cure have been depressingly fruitless.
Depressingly, treatments do not seem to be advancing as they have done with adult cancer.
The age-old pay gap between men and women is, depressingly, as strong an institution as ever.
The best research seemed to show, depressingly, that nothing works that rehabilitation was a ruse.
But the texture of Theresa's improbable flirtation with this septuagenarian rake is depressingly innocent.
Depressingly for football fans, it is not going to be easy or quick to change.
But if terrorism is new to Jaipur, it has become depressingly familiar to India.
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The current crisis is a sort of super-sized, IMAX version of a depressingly familiar horror film.
Depressingly, today it is less apparent that Netanyahu has in fact abandoned their legacy of defeat.
There is no debate going on and the result will be one-sided and depressingly divisive.
But unlike Americans, Britons like their reality to be depressingly, and sometimes tediously, real.
The report said despite the clear consensus over what diabetes patients needed, performance had been "depressingly poor".
Depressingly, under the Obama administration the US will not lift a finger to support Syrian regime opponents.
The threadbare charges and countercharges being hurled from the chambers of the failed deficit supercommittee are depressingly predictable.
These vested interests always complain, with depressingly predictable outrage, about every change to a system which is failing.
Yet against that depressingly familiar backdrop, some fundamental numbers are moving in the right direction (see article).
How we got here is depressingly familiar in an age of financial mis-engineering.
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Depressingly, the first act of the new Congress government in Andhra Pradesh was to restore free electricity to some farmers.
This is depressingly rare in the former Soviet Union, and it ought to be cheered enthusiastically regardless of the specific outcome.
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It felt as if a profoundly important issue had been touched - but one which was depressingly far from being resolved.
While the PC has gotten easier, newer technologies, such as wireless home networking, are as depressingly complicated as computers once were.
Instead, as Mr Freddoso rather depressingly finds, Mr Obama spent the whole period without any visible sign of rocking the Democratic boat.
For those familiar with China's banking reforms, such setbacks are depressingly familiar.
Stalemate, gridlock, and lack of public confidence: it all sounds depressingly familiar.
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Copenhagen made depressingly clear that "political realism" has trumped "climate realism" and that the "G2" powers are incapable of providing global leadership.
The sad truth for Mr Cameron and Mr Brown is that like Harold Macmillan with JFK alongside Mr Obama they will both look depressingly plain.
Policy entrepreneurs piggyback on zombies to capture attention, but they too often overlook a key element of zombie stories: They are relentlessly, depressingly apocalyptic.
This feel-good comedy, directed by Ron Underwood from a script by Lowell Ganz and Babaloo Mandel, is a depressingly efficient piece of Hollywood product.
Today US forces in Afghanistan are fighting in a manner that is depressingly similar to that forced upon IDF forces in Lebanon in the 1990s.
Begin with the depressingly long list of reasons to be pessimistic.
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