Depression, which affects many people within society, stands out as a major area for development in the mood foods category. 25% say there is strong growth potential and 51% average growth potential for NPD in 2012.

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Sayre believed that many medical conditions had their root in a dysfunction in the genital area, and that circumcision could be used to treat a startling array of problems, from depression to mental health issues, syphilis and epilepsy.

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This wave known as "cortical spreading depression" activates nerve cells as it goes, and the symptoms sufferers report typically correspond to the area of the brain the wave is passing over.

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Merck faces heavy competition in almost every area of brain research, especially from Pfizer, which has been working on substance P blockers for depression and on new, safer antianxiety drugs.

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Additionally, corporates in the area will also be affected negatively by the downgrades, this will tend to decrease value and compound price depression in the respective regions.

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