Despite some limitations of trial design, including the open label nature of the study, RECORD remains the only randomized trial of cardiovascular outcomes for Avandia at this time.

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Unfortunately, the reviewers found that limitations in the design of the trials, their conduct, and the way they were reported precluded any conclusions about the effect of the drug on complications.

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The limitations of responsive design in adapting for use case and context means that it is more hindrance than help in mobilizing distinct, device-specific experiences that impart user value, such as more complicated web applications.

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There are limitations to the accepted design, pointed out by the joint rival pitch from Nokia, RIM, and Motorola.

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Today the engineers have been able to design fewer antennas into these devices by making one antenna do the work of several, but there are limitations about what can be done.

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