But abdominal distension - being permanently bloated - was more frequently associated with a diagnosis and was a symptom present even in the earlier stages of disease.

BBC: Ovarian cancer 'is being missed'

Other common adverse reactions, reported by 5 to 7 (17-24%) patients, included weight loss, abdominal discomfort, abdominal distension, constipation, flatulence, increased ALT, chest pain, influenza, nasopharyngitis, and fatigue.

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This bacterium, which causes life-threatening distension of the gut in some people who have been treated with antibiotics and thus had their microbiomes disrupted, is a bane of hospitals.

ECONOMIST: Modern medicine

In CIC clinical trials, the most common side effect were diarrhea (16% vs 5% placebo), abdominal pain (7% vs 6%), flatulence (6% vs 5%), upper respiratory tract infection (5% vs 4%), sinusitis (3% vs 2%) and abdominal distension (3% vs 2%).

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