However, a triple therapy combination of a diuretic with an ACE inhibitor or ARB and an NSAID was associated with a 31% higher rate of kidney injury, particularly elevated in the first 30 days of treatment during which it was 82% higher.

FORBES: Acute Kidney Injury Associated With Dual Antihypertensive Therapy And NSAIDs

The results show that patients taking a double therapy combination of either a diuretic or an ACE inhibitors or ARB with an NSAID were at no increased risk of kidney injury.

FORBES: Acute Kidney Injury Associated With Dual Antihypertensive Therapy And NSAIDs