Douglas Hodge will take the lead role in Osborne's play, about a middle-aged lawyer facing a midlife crisis.
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The trio, who each play Billy, face Ewan McGregor and Douglas Hodge from Guys and Dolls, which has eight nods.
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Gillan, who plays the Doctor's feisty assistant Amy Pond, will appear with Douglas Hodge in the show, which opens at the Donmar Warehouse in October.
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Also starring in the show - which opens at London's Piccadilly Theatre on 1 June - are Jenna Russell, Douglas Hodge and Ally McBeal actress Jane Krakowski.
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