Rational drug design, the hallmark of new-school biotech, is no panacea, as Gladwell rightly points out.
In the long term, genetic signatures are also throwing up new leads for anticancer drug design.
The drug was originally developed as Imatinib using rational drug design after Philadelphia chromosome mutation was discovered.
FORBES: India Court Ruling Against Novartis Is Dark Omen For Big Pharma
The genes make proteins and these proteins are the starting points for drug design, known as drug targets.
Instead, it incorporates elements of physics and chemistry into several new degree courses such as toxicology, drug design and sports science.
San Diego is Pfizer's center for structure-based drug design, which uses computers to map disease-causing proteins and suggests ways to thwart them.
PolyMedix, a company that is developing drugs made by a proprietary computational drug design system to mimic natural germ-killing proteins found in humans.
Drug traffickers design SPSS to rapidly sink when they detect law enforcement thereby making contraband recovery difficult.
Kindler also lured Neil Gibson, formerly chief scientific officer at biotech OSI Pharmaceuticals, to head oncology research, and Briggs Morrison, a former oncologist who made clinical trials run faster at Merck, to design drug studies.
Kindler also lured Neil Gibson, formerly chief scientific officer at biotech OSI Pharmaceuticals, to head oncology research, and Briggs Morrison, a former oncologist who made clinical trials run faster at Merck (nyse: MRK - news - people ), to design drug studies.
While the FDA regularly sends out warning letters to medical device and drug companies over design flaws or diverted and contaminated drugs, the SynchroMed case stands out because Medtronic is a known innovator in the medical device space, so it is surprising it would not act sooner to resolve the issue.
FORBES: Medtronic Sees Revenue Growth Despite Unaddressed Quality Concerns
So he teamed up with a chemist, Michael Jung, at UCLA to design a drug themselves.
Such thinking permits the design of drug molecules to treat complex human diseases or to modify other difficult biological disorders.
Just a few years ago researchers had naively hoped that they could design a drug to blast a single cancer-causing protein and send the disease into remission for years without forcing the patient to endure the side effects of prolonged toxic chemotherapy.
Trying to design a new drug or vaccine from the ground up is one of the riskiest gambles a corporation can take.
But many small companies rely on repeated equity financings to keep their research going for the 15 years it can take to design a new drug.
Working at this crossroads has enabled him to make huge leaps in the field of drug delivery systems and to design biodegradable polymers on which human tissue can grow.
Mutual and the Obama administration want that protection extended to the design of the drug, since the generic is an exact copy of the brand-name drug that has already been approved by the federal government.
Mutual, however, argues that federal law preempts this type of claim, because the FDA had already approved its drug and federal law also requires a generic drug to have the same design as the brand-name medication ( here is the petition).
FORBES: Good For Generic Drugmakers? White House To Argue In Favor Of Preemption
In the early 1990s he saw a PBS program on the microprocessor and Intel and hit upon another notion: Why not design a microchip for drug release?
How would making the proposed changes to the design and production of the drug make it safer for the environment?
Best of all would be to design new versions of the drug ones with the desirable properties but none of the side-effects.
Normally it takes nine months to design a late-stage drug trial.
Tularik announced after Monday's close that the U.S. Food and Drug Administration has green-lighted the design of what could be the final clinical tests for the South San Francisco-based biotech's liver cancer drug, T67.
With the social enterprise mPedigree Network, HP leveraged its technology expertise in cloud-based services to design and build an anti-drug counterfeiting service in Africa.
At issue is whether a generic drug maker can be held liable for a design flaw if it failed to withdraw an allegedly harmful medicine from the market.
FORBES: Good For Generic Drugmakers? White House To Argue In Favor Of Preemption
Eric Park, of Ziba, a design consultancy, reckons companies must also think about drug delivery systems and patient-friendly packaging, which could create a new kind of branded intellectual property that might be more defensible than drug patents.
Some researchers worried an mTOR drug would suppress patients' immune systems, as Rapamune does by design.
Bartlett that federal law preempts design-defect claims against the manufacturer of a generic drug.
Lead optimisation is a key stage in the drug discovery process, where early leads are improved through cycles of design, synthesis and testing to identify potential drugs which are suitable for testing in a clinical setting.
应用推荐