Home Office pathologist Dr Stephen Leadbeatter told the inquest that drug toxicity had been the cause of Laura's death.
BBC: NEWS | UK | Wales | South West Wales | Girl's overdose after 'bullying'
The hepatocytes produce the enzymes needed to break down toxins, so these little microlivers can be used to test drug toxicity.
If the amyloid theory is right, anti-amyloid drugs are still highly unlikely to be a cure. (One reassuring possibility is that the bad Eli Lilly result was due to a drug toxicity, not its effect on amyloid.) Only a handful of the drugs that hit the market early will snag most of the sales, if things go the way they usually do.
FORBES: Eli Lilly Setback Could Pave Way For New Alzheimer's Approach
It licensed its first DPP-4 inhibitor in 2000, but the drug caused toxicity in lab animals.
Further trials of this compound are on hold because the drug caused cardiac toxicity at high doses in animal tests.
But the drug's potential toxicity still was a problem, and ProScript was running out of cash.
The drug had caused muscle toxicity in earlier tests, but Tally's team changed the dosage and minimized the problem.
Kadcyla will carry a boxed warning, the most severe type, alerting doctors and patients that the drug can cause liver toxicity, heart problems and potentially death.
Two months ago it halted trials of a promising arthritis drug over fears of brain toxicity.
Geron and GE Healthcare, a division of General Electric, are developing and commercializing cellular assay products derived from human embryonic stem cells for use in drug discovery, development and toxicity screening.
General Electric ( GE - news - people ), are developing and commercializing cellular assay products derived from human embryonic stem cells for use in drug discovery, development and toxicity screening.
This month Vertex plans to present initial efficacy results for a drug it believes will avoid the toxicity problems of Boehringer's compound.
The drug was only in a Phase I trial that is, a trial designed to determine the toxicity of a range of doses, not whether the drug worked.
The device saves time with its speed and because it provides critical toxicity data early on in the drug discovery process.
If the drug doesn't work, or it has toxicity, we need to find that out.
But an increase in liver toxicity for TAK-475 would make drug companies reticent to try to make better versions that work in the same way.
Steven Gill, the British neurosurgeon who ran that first GDNF infusion trial, believes the cause of the toxicity was the improper infusion of the drug into the monkeys' brains.
New food products must endure the same costly testing for toxicity as drugs, but do not offer drug-like returns.
Embryonic stem cells have also caught the eye of drug companies, which aim to use them to test potential drugs for effectiveness and toxicity.
The remotest hint of liver or heart toxicity in just a few patients among thousands is enough to send a drug back for several more years of testing.
One possibility is that the amyloid theory is right, but that the Eli Lilly drug is flawed and did not hit the proper molecular target, and ended up merely causing toxicity.
FORBES: Eli Lilly Alzheimer's Disease Failure Bolsters Amyloid Theory Skeptics
It was originally dropped as a treatment for high cholesterol by Bristol-Myers Squibb because of the liver toxicity issues, but a University of Pennsylvania cardiologist, Daniel Rader, championed the drug, leading Aegerion to develop it.
FORBES: Aegerion Cholesterol Drug Approved. Will It Treat 300 Patients, Or 3,000?
First, the active drug would have to be present in the food at sufficient levels to exert an adverse effect via direct toxicity or allergy.
Nanoscale materials are being used to address current drug delivery shortcomings, including water solubility, ADME (absorption, distribution, metabolism, and excretion) and toxicity.
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