Some children as young as age 3 show early signs of gender dysphoria, or gender identity disorder, mental health experts who work with transgender children say.

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Wolmark said he felt "dysphoria" presenting positive results for a drug that had never reached the market in the U.S., and joked that U.S. oncologists could simply forget about the data after he had presented them.

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The huge panorama of problems, issues, untoward thoughts, negative emotions, conflicts, sensory dysphoria, interpersonal ineptitude, and intrusive images that bring most people to therapists far outweigh the relatively small number of complaints that are thus far amenable to empirical methods and manualized therapy.

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