Toward the end of their run Neanderthals were reaching adulthood three to five years sooner than we were.
According to Arvind Bhatia, video game analyst at Sterne Agee, 2K Sports should sell 4.5 million copies worldwide by the end of its run.
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The move is something of a surprise, as producers had been reportedly looking for an actor to replace Radcliffe, 17, at the end of his run.
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Now, mind you, there are cyclical aspects to all markets and it may well be that the initial signs of trouble were simply the indications of the end of a run.
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Inspired by the brilliance of Tevez, he has been able to piece together a superb end of season run, capped with a win at champions Manchester United to seal an unlikely escape.
Blackpool boss Ian Holloway, in contrast, will be delighted to see his side register only their second home league victory of the season and end a run of three games without a win.
Crafting the first several installments was as agonizing as a trip to the dentist, but by the end of the run, at least I knew exactly where my characters and story were going.
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The more ground they cover, the more likely they are to discover batteries, medical supplies or other equipment, which can be allocated at the end of the run to different parts of the base.
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Additionally, if the stock is exhibiting abnormally higher than average volume, or continues to advance until it is extended 70% to 100% above its 200-day moving average, it may be approaching the end of its run or running out of buyers, and it may be time to cash in my shares.
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The goal is the first Liverpool have conceded in over seven hours of football and the draw brings to an end a run of four successive wins for Dalglish's side.
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As he nears the end of this White House run (he is leaving office at the end of the year), he had specific deficiencies in mind when I and others queried him on that score.
And John Sutton doubled the Steelmen's lead at the end of another enterprising Humphrey run 20 minutes from the end.
Lomax could not land the extras but Saints held on to end their run of two straight defeats.
It was a hard-earned win for Linfield against a Ballymena team desperate to end a run of defeats.
Michigan Governor Rick Snyder appointed an emergency manager at the end of 2011 to run the cash-strapped city.
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In 1995, Fry walked out during a West End run of Simon Gray's Cell Mates claiming stage fright.
The screeching halt of transaction volume marks the end of quite a run.
Ireland will be aiming to end a run of four straight Test defeats.
The home side were out to end a run of five successive Magners League defeats and dominated the early exchanges.
Kruger got his revenge, in consecutive overs bowling Carter and Jim Troughton, to end his run of three straight half centuries.
Palace take on Cardiff City at Selhurst Park on Saturday looking to end a run of five home defeats in six matches.
In the English Premier League, 10-man Liverpool beat relegation haunted Blackburn 3-2 at Ewood Park to end a run of three defeats and a draw.
Pakistan, looking to end a run of 12 consecutive defeats to Australia in Tests stretching back to the 1990s, cannot be too confident despite the scoreboard.
If history repeats, investors should be booking profits on this strength, not piling on to what could be the end of a momentum run for stocks.
The Kansas Supreme Court recently held that doctors can be sued under that state's consumer protection law, as a kind of end run around traditional malpractice suits.
All-rounder Flintoff is keen to end a run of eight England Test defeats in his last eight appearances when the final Test of the series with South Africa starts.
He replaces Joseph Lhota, who served less than a full year as MTA chairman before departing at the end of 2012 to run for New York City mayor as a Republican.
And despite the best efforts of Ramnaresh Sarwan (57) and Lendl Simmons (62), the required run rate climbed to 7.22 towards the end of a 125-run stand which soaked up 27 overs.
But the Edinburgh side survived late Dons pressure to end a run of three games without a win, although they had been unbeaten in their last seven before losing to Celtic in midweek.
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