When the enzyme activity slows, levels of those substances climb.
Researchers can only use dead cells or pieces of a cell and can only test for one response at a time, such as enzyme activity or the binding of a compound to a receptor.
In the circadian-gene mutants, however, the enzyme's activity stays steady after a dose of the drug, so tyramine levels remain low.
And the machines can only test for one event at a time--say, monitoring one enzyme's activity or seeing if a compound binds to a target on a cell.
Dr. SPIESEL: You swallow it and it enters the intestinal contents and it blocks the activity of an enzyme called lipase.
Researchers in Iceland identified a rare genetic mutation that slows the activity of an enzyme called beta secretase, which is required to produce amyloid-beta.
If too little acetylcholine is part of the problem, then it might be possible to tackle the deficiency by inhibiting the activity of this enzyme.
The eight-week study found that people who meditated showed a 43% improvement in telomerase activity, an enzyme that regulates telomere length, compared with a 3.7% gain in the group listening to music.
One works by inhibiting the activity of a viral enzyme called reverse transcriptase.
Just one square inch, the chip contains 2, 056 microvalves that can selectively mix reagents together (in this case to test for the activity of a particular enzyme in a bacterium) in 256 reaction chambers, each one holding less than one-billionth of a liter of fluorescent dye.
The drugs are thought to enhance the activity of SIRT1, a key enzyme involved with the aging process.
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