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The mutation freezes a crucial protein called epidermal growth factor receptor in the "on" position.
FORBES: Taking Aim at Brain Cancer
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All three drugs target the epidermal growth factor receptor (EGFR), a protein that is over-expressed in cancer cells.
FORBES: Magazine Article
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One reason could be that epidermal growth factor, the protein Iressa blocks, wasn't the right one to begin with.
FORBES: Magazine Article
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The process, called a cultured epidermal autograft, was done more than 100 times in the United States last year, according to Genzyme.
CNN: STORY HIGHLIGHTS
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Both pills inhibit a receptor for a protein called the epidermal growth factor (EGF) that many tumors seem to depend upon to grow.
FORBES: Magazine Article
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The molecule - epidermal growth factor receptor (EGFR) - relays instructions to cells to grow and divide, and to ignore signals telling them to die.
BBC: NEWS | Health | Smart drug for lung cancer tested
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Hunting for other targets in the early 1980s, he focused on a protein called epidermal growth factor, or EGF, then a hot area of research.
FORBES: A Homegrown Pipeline
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Lapatinib, it turns out, also inhibits the activity of a protein called the epidermal growth factor receptor, which has been found to be important for stem-cell proliferation.
ECONOMIST: Cancer therapy
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The public has mostly focused on Erbitux's ability to slow tumor growth by blocking epidermal growth factor receptor, a key growth-promoting protein that is overabundant in many cancer cells.
FORBES: Bristol, ImClone File On Erbitux
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The new technology, called an epidermal electronic system (EES), is based on a new class of micro-electronics that integrates miniature sensors, light-emitting diodes, tiny transmitters and refined wire-filament receivers.
FORBES: Electronic Devices Packaged in Synthetic Skin