His scoring average of 67.8 was 1.5 strokes better than the second place finisher, Ernie Els.
Ernie Els took 70 for three under with USPGA champion YE Yang at two under.
Among the five who posted 69s were two former Open champions, Jim Furyk and Ernie Els.
Current Open champion Ernie Els is among those one further back following a disappointing 72.
"It was unbelievable what he (Ernie Els) did for me, " Oosthuizen told the official British Open website.
Golf's presentation video included stars of past and present including Jack Nicklaus, Phil Mickelson, Ernie Els and Woods.
Mickelson ended alongside Ernie Els, Dustin Johnson and Ryo Ishikawa with Paul Casey in a group at even par.
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As this season winds down, the calendar is working against Mickelson and Ernie Els, who each have four majors.
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Woods has been paired with Ernie Els and US Open champion Graeme McDowell.
British Open champion Ernie Els tied for 48th after his second successive 73.
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The Surrey course has been extensively remodelled according to recommendations made by three-time major winner and local resident Ernie Els.
Victories quickly followed for Hunter Mahan over Camilio Villegas, Anthony Kim against Robert Allenby and Sean O'Hair over Ernie Els.
Phil Mickelson went into the clubhouse on six-under 136, two ahead of British Open champion Ernie Els of South Africa.
South African Ernie Els, looking to and become the first player to win the tournament twice, carded a three-under-par 69.
Fello South African Ernie Els shot a steady 69, Spain's Sergio Garcia a 70 and England's Lee Westwood a 71.
He was bracketed at nine-under with, among others, Luke Donald (72), Ernie Els (70), Padraig Harrington (71) and Justin Rose (68).
World number three Ernie Els, Henrik Stenson, Luke Donald, Lee Westwood and ninth-ranked Vijay Singh are also among the strong field.
Woods has already had one knee operation and look at Ernie Els - his knee injury could have been career threatening.
Ernie Els' first round 60 last year suggests that not only is that possible, he could be the man to shoot it.
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Defending champion Rock finished on 76, while Ernie Els, playing alongside Rock and Rose, had a 71, the same as Martin Kaymer.
Woods' much vaunted head-to-head clash with world number two Ernie Els was a massive disappointment, with the South African finishing 19 shots behind the winner.
And there will be 11 major winners in the field, including current Masters champion Angel Cabrera, Ernie Els, Trevor Immelman and Retief Goosen.
Goosen, the European number one in 2001 and 2002, is second in the standings and could narrow the gap on countryman Ernie Els.
Ernie Els' SA Open victory, his first of the year, lifts him from eighth back to the fifth spot where he started the year.
There were other high-profile departures in the form of 2011 U.S. PGA champion Keegan Bradley, Lee Westwood and 2012 British Open winner Ernie Els.
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Also on 12 under was South African three-time major winner Ernie Els, who led the field on 14 under with just three holes to play.
South African superstar Ernie Els sports a lion, while Australian Aaron Baddelly opts for a Koala Bear and Justin Leonard has a Yellow Lab.
The 51-year-old Australian will join the likes of Tiger Woods, Ernie Els and Colin Montgomerie in the field at the Emirates Golf Club from 1-4 February.
Scotland's Montgomerie, runner-up to Ogilvy last year, lost out to South African Ernie Els the last time the US Open was held at Oakmont in 1994.
BBC: Ramsay, 23, won the US Amateur at Hazeltine last August
The Northern Irishman won by one shot from France's Gregory Havret with Ernie Els two behind in third and Phil Mickelson and Tiger Woods tied fourth.
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