Mr. ED LANK (University of Maryland): The classical design performed the way it was designed, except this particular failure mechanism was not considered.
Anyone quick to dismiss this potential problem need only think back on our humbling recent experiences with ICD failures to recognize that the late manifestation of an unanticipated failure mechanism is a fact of reality in cardiac rhythm devices.
In essence, I believe this was not a failure of the drug or the mechanism but a failure of us as investigators to make sure we had sufficient disease in our population upon which to test our hypothesis--somewhat akin to trying to show one antibiotic is better than another or even a placebo, but selecting a population with no infection!
The failure of the voting mechanism also shows that Facebook itself needs to rethink how it proposes changes and how it deals with the aftermath.
FORBES: News Flash: You Never Really Had A Vote On Facebook Anyway
Failure is actually the mechanism by which learning happens.
FORBES: The $100 Higher Education: Chris Guillebeau on Inexpensive Startups as Real-World Education
Dr Unger and Dr Scherer suggest that this failure of the leptin mechanism, particularly its role in oxidising lipids, is crucial to the development of metabolic syndrome, and that it is a pathology of adipose tissue that has become overloaded.
Vilayanur Ramachandran, a researcher at the University of California, San Diego, thinks he may have found that mechanism: a failure of what are known as mirror neurons.
The politicians are leaving all the details, including who will do the cutting, how the trading mechanism will work and what the penalties for failure will be, up to the agency that enforces the state's existing air-pollution standards.
But doctors are plagued by avoidable failure and the medical profession as a whole has no reliable mechanism for learning from its mistakes.
It goes on to say that although the precise mechanism by which the food came to be contaminated cannot be established, "the outbreak revealed a failure of routine hazard control systems within the kitchen".
应用推荐