As many of you know, Secretary Clinton became the first Secretary of State since Dean Rusk, in 1961, to go to Asia on an inaugural trip.
Of course, Hillary wasn't the first secretary of state to advocate for human rights or use the post to raise awareness of abuses or negotiate humanitarian relief or pressure oppressors.
His original title was deputy prime minister and first secretary of state for environment, transport and the regions - "the only minister with a job title bigger than his vocabulary", according to Sir Norman Fowler.
And he certainly isn't the first secretary of state for Wales to do so - Labour's Paul Murphy faced flak for taking a similar journey (albeit in a more humble Vauxhall Vectra) more than a decade ago.
The business secretary, who was last week given the additional title of first secretary of state, said he would not "lose any sleep" over the threat posed by those Labour MPs who opposed Mr Brown's leadership of the party.
Lord Mandelson, the First Secretary of State, has himself been at the centre of fresh leadership speculation in the past few days with bookmakers slashing the odds on the prospect of Lord Mandelson returning to the Commons and succeeding Gordon Brown.
First, Secretary of State Condoleezza Rice met with Israeli officials today about ways to end the fighting with Hezbollah guerillas in Lebanon.
"Something that was not on the table a few weeks ago is the international financial crisis, " said Albright, who became the first female secretary of state while serving in the Clinton administration from 1997-2001.
In an interview with NPR's Juan Williams, Albright discusses what it was like to be the first female secretary of state, her opinion about the timing of the recent war in Iraq and the lessons of the U.S.-led war in Kosovo.
The disclosure came as John Kerry arrives Friday in Asia for his first tour as secretary of state through a region more on edge than it has been in years.
The child of Jamaican immigrants, Powell is in line to become the first African-American Secretary of State.
It was one of the first policy decisions taken by the secretary of state for Wales after the general election.
Paradoxically, the ultra-cautious Mr Weinberger may be seen as the forerunner of Colin Powell, George Bush's first and oft-overwhelmed secretary of state, whereas Mr Shultz had more in common with Mr Rumsfeld, at least as far as the use of force was concerned.
Clinton is scheduled to depart Sunday for her first overseas trip as secretary of state.
John Kerry's first overseas trip as secretary of state is taking him to 11 countries in Europe and the Middle East.
The crisis in Syria has been a central issue in John Kerry's first overseas trip as secretary of state, which is taking him to 11 countries in Europe and the Middle East.
The first contradiction pits former Secretary of State Hillary Clinton's explanation of security conditions at the compound against that of Eric Nordstrom, the former regional security officer at the U.S. Embassy in Tripoli.
Party president Gerry Adams led the Sinn Fein delegation at their first meeting with the secretary of state, since the parties returned last week from St Patrick's Day celebrations at the White House in Washington.
Clinton, who returned from Asia on Sunday after her first overseas trip as secretary of state, called North Korea's nuclear program "the most acute challenge to stability in northeast Asia" and has said there is a "testing period" at present about how diplomacy can move forward.
The man who succeeded Baker as the first President Bush's secretary of state was Lawrence Eagleburger.
Mr Gilmore joined the First Minister Peter Robinson and Secretary of State Theresa Villiers who led the wreathlaying.
The eyes of the world's media have been focused on Burma this week, for the first visit from a US Secretary of State since since 1955.
The trip represents a departure from a diplomatic tradition under which the first overseas trip by the secretary of state in a new administration is to Europe.
Who has been first lady, senator, secretary of state?
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Clinton became the first U.S. secretary of state to attend the East Asia Summit, a gathering of 10 Southeast Asian nations and other regional powers, such as China, South Korea and Japan.
WSJ: Clinton Presses China to Do More to Restrain North Korea
First this, in London Secretary of State Condoleezza Rice is dividing her time between meetings about the Middle East and the radical Palestinian group Hamas, we covered that story earlier in the show, and other meetings about Iran's nuclear program.
Mr Kerry is making his first trip to Asia since becoming secretary of state.
The violence comes amid the first overseas trip by new US Secretary of State John Kerry.
The Secretary of State, first and foremost, wants the Canadians to continue, as you mentioned, to be involved.
Irish Foreign Minister Eamon Gilmore, who is also the deputy prime minister, described the meeting with the secretary of state and First Minister Peter Robinson and Deputy First Minister Martin McGuinness as "positive and productive".
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