First, ending the stalemates on the Fissile Material Cut-off Treaty and the Comprehensive Nuclear Test Ban Treaty.

BBC: In full: Brown security statement

He outlined five areas to focus on, including the need for a verifiable and legally binding fissile material cut-off treaty and a possible follow-up meeting in New York to the 2009 Security Council summit hosted by President Obama.

UN: Secretary-General

Together with Obama administration officials' calls for Israel to join the Nuclear Non-Proliferation Treaty - which would compel Israel to relinquish its purported nuclear arsenal - and their stated interest in having Israel sign the Fissile Material Cut-off Treaty - which would arguably force Israel to allow international inspections of its nuclear facility in Dimona - Obama's planned nuclear conclave will place Israel in an untenable position.

CENTERFORSECURITYPOLICY: Netanyahu's perilous statecraft

The going for a fissile-material cut-off treaty at the log-jammed Conference on Disarmament could be harder still.

ECONOMIST: Nuclear disarmament