Bath flanker Moody, 32, is recovering after tearing ligaments in his right knee on 15 January.
Flanker Ally Hogg believes inexperience was a factor in that first Test loss in Rosario.
Portugal flanker Joao Uva was then sin-binned for 10 minutes after persistent handling on the floor.
Fly-half Flood suffered a shoulder injury against France, while flanker Worsley suffered a gashed right thumb.
Flanker Michael Lipman and full-back Nick Abendanon replace Lewis Moody and Tom Varndell in the squad.
Flanker Schalk Burger is also a doubt after he injured his knee on Friday.
Flanker Martyn Williams, Wales' most experienced player with 81 caps, hailed Edwards' impact as "unbelievable".
James followed flanker Gavin Thomas and New Zealand lock Simon Maling out of Parc y Scarlets.
New Zealand prop John Afoa was suspended and flanker Chris Henry was ruled out with injury.
The head coach was a former openside flanker for the British and Irish Lions.
Flanker Martyn Williams, named man-of-the-match, sealed victory with Wales's second try three minutes from the end.
However, the flanker had outstripped his support and was forced to hold on in the tackle.
Blues flanker Maama Molitika and fly-half Ceri Sweeney touched down while Blair's kicking proved the difference.
Welsh coach Warren Gatland has revealed the importance of the veteran openside flanker to his country.
Scotland flanker Ally Hogg said the side were disappointed with their display at Murrayfield.
The Ireland flanker tore the medial collateral ligament in his right knee in training on Monday.
Welsh flanker Dan Lydiate scored in the 74th minute, taking the Lions' total over the half-century mark.
The flanker is in his first year with Heineken Cup quarter-finalists Northampton after three seasons at Worcester.
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Veteran flanker Williams may have been fortunate not to be banished to the sin-bin for that offence.
Biarritz flanker Thierry Dusautoir was sin-binned five minutes before the break for deliberately slowing the ball down.
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And flanker Peter Buxton believes Ryan will want to complete the job he has started at Gloucester.
Flanker Roddy Grant's converted try had Edinburgh 21-19 up but Nikora coolly stroked over the telling score.
Connacht's frustration was compounded as flanker John Muldoon was yellow-carded for dangerous driving play at a ruck.
John Barclay was outstanding for the visitors, the flanker claiming two tries in a hearty all-round display.
The Dragons, who are also looking to recruit an open-side flanker, have parted company with Lee Hinton.
The uncapped pair of flanker Heinrich Brussow and Golden Lions fly-half Earl Rose miss out all together.
Captain Berrick Barnes added a penalty and a drop-goal before flanker Scott Higginbotham went over in injury time.
Paterson converted before flanker Kelly Brown increased Scotland's lead with a try following good work by Rory Lamont.
Edinburgh flanker Fraser McKenzie could make his Scotland A debut in Belfast if he comes off the bench.
David Pocock comes in for flanker George Smith in Australia's only change from the side which beat England.
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