At the time the hot research area was in testing G-protein-coupled receptors, or GPCRs.

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These included genes involved in the regulation of three neurotransmitters dopamine, glutamate and serotonin and also G-protein-coupled receptors, which react to a wide variety of stimulants.

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At the time, the hot research area was in testing G-protein-coupled receptors, or GPCRS. These proteins transmit chemical signals into a wide variety of cell types.

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Noting that its basic structure resembled that of other receptors, he also came to understand that there exists an entire family of similar receptors, now widely known as G-protein-coupled receptors, or GPCRs.

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Peroxynitrites contribute to the hyperphosphorylation of tau proteins by oxidating g-protein coupled receptors and trysoine kinase receptors preventing protein kinase C and AKT from inactivating the enzyme GSK3 which is necessary to prevent the hyperphosphorylation of tau proteins.

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Cadus is using yeast to identify a class of proteins known as G protein-coupled receptors.

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