At the time the hot research area was in testing G-protein-coupled receptors, or GPCRs.

FORBES: The Next Fat Pill

At the time, the hot research area was in testing G-protein-coupled receptors, or GPCRS. These proteins transmit chemical signals into a wide variety of cell types.

FORBES: The Next Fat Pill

Noting that its basic structure resembled that of other receptors, he also came to understand that there exists an entire family of similar receptors, now widely known as G-protein-coupled receptors, or GPCRs.

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Peroxynitrites contribute to the hyperphosphorylation of tau proteins by oxidating g-protein coupled receptors and trysoine kinase receptors preventing protein kinase C and AKT from inactivating the enzyme GSK3 which is necessary to prevent the hyperphosphorylation of tau proteins.

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Cadus is using yeast to identify a class of proteins known as G protein-coupled receptors.

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