The gene mutation ends up causing lower-than-normal production of a protein called ApoCIII.
CNN: Gene mutation protects against milk shakes and other fatty fare
By contrast, Japanese patients with another gene mutation were found to have high HDL but no evidence of benefit.
His tumor had a gene mutation being targeted by a new cancer vaccine being tested by Duke neurosurgeon John Sampson.
Hoffman at UC, San Diego in 2001 pinpointed the gene mutation that causes Muckle-Wells and the inherited overreaction to drafts.
Bristol-Myers and ImClone could lose a significant chunk of sales as doctors stop using it in patients with the gene mutation.
But Italian researchers 27 years ago discovered one family whose HDL levels were lower than 15 because of a gene mutation.
The German researchers examined the body weights and DNA of 181 relatives of 25 extremely obese patients who carried the gene mutation.
The best Elan trial results unexpectedly came in the subset of about 35% of patients who lack a gene mutation called APOE4.
The rarer oculocutaneous albinism type 3 is caused by a gene mutation on chromosome 9 and has been primarily identified in black South Africans.
It did not reach its main efficacy goal in a second-trial trial, but did help a subset of patients without a certain gene mutation.
Just this week, Italian researchers pinpointed another gene mutation present in about 10% of colon cancer patients that appears to render Erbitux and Vectibix ineffective.
But there were chemotherapy options, notably a relatively new drug called Tarceva, which targets a gene mutation commonly found in lung cancers of female non-smokers.
Scientists from the Centre for Research on Women's Health in Toronto led the study which looked at women with the BRCA1 and BRCA2 gene mutation.
It shrunk tumors in 10 of 18 lung cancer patients with a particular gene mutation that occurs in 5% of lung cancers, often in younger nonsmokers.
Novartis is in final trials of a drug that may help the one-third of acute myeloid leukemia cases with a gene mutation that turns on cell-growth signals.
She developed an aggressive form of breast cancer at age of 31, and later learned she had a gene mutation that's been linked to breast and ovarian cancer.
The medicine basically undid five years of lung deterioration for patients who took it, but will only work for those whose CF is caused by a specific gene mutation.
Oculocutaneous albinism type 4, caused by a gene mutation on chromosome 5, is an uncommon form of the disorder generally presenting signs and symptoms similar to those of type 2.
The goal is to try to find the best place to intervene with a drug, rather than just going after whatever tumor gene mutation happened to be discovered most recently.
Late Tuesday afternoon, the companies presented mediocre trial results showing that bapineuzumab (b-mab for short) didn't work overall in an 18-month second stage trial but seemed to help a subset of patients who lack a certain gene mutation, APOE4.
In the trial, which included 55 patients, tumors dramatically shrank in 9 of 16 very advanced patients with the gene mutation who got high doses--a better response rate than doctors have remembered seeing in a trial for advanced melanoma.
But for the average breast cancer patient who has neither the BRCA1 or BRCA2 gene mutation nor a close relative with breast cancer (Jolie's mother, for example, died from ovarian cancer), the risk of a new breast cancer in the nonaffected breast is less than 1%.
The discovery of the FOXP2 brain gene, a mutation of which can cause language loss, was met with considerable excitement when it was announced over a decade ago.
ECONOMIST: What makes some people learn language after language?
Oculocutaneous albinism type 1 is caused by a mutation in a gene on chromosome 11.
Oculocutaneous albinism type 2 is caused by a mutation in a gene on chromosome 15.
Apparently, a mutation in this gene or, more probably, in the control system that activates it gave rise to Volvox.
Roche's drug, called PLX4032, targets a mutation in a gene called BRAF that appears to be an important growth driver in 60% of melanoma cases and is also found less frequently in many other cancers.
The emerging data, much of it being released at a big meeting of cancer specialists this weekend in Chicago, reveal that Erbitux is utterly ineffective in about 40% of colon cancer patients whose tumors have a mutation in a gene called kras.
In 2002 gene researchers in the U.K. discovered that two-thirds of melanomas have a mutation in a growth-promoting gene inside skin cells called BRAF.
Herceptin is a breast cancer drug that was developed to treat tumors that have a specific mutation in the Her2 gene.
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