The drug's future could be complicated because it also lowers good cholesterol and raises bad cholesterol.
Torcetrapib aims to raise good cholesterol, or high-density lipoprotein, by blocking the cholesterol ester transfer protein.
Esperion's pipeline was an obvious threat to Pfizer's most important experimental drug, which raises good cholesterol.
High-density lipoprotein, better known as HDL or "good cholesterol, " has become a medical mainstay.
Last November Pfizer announced the failure of torcetrapib, a drug to boost good cholesterol (HDL).
Niacin was always known to raise good cholesterol and appears also to prevent heart attacks.
ETC-216 is a slightly different version of a protein in high-density lipoprotein, the so-called good cholesterol.
For a few years it thought it had one: good cholesterol, also known as high-density lipoprotein.
Alcohol, including beer, in moderation raises high-density lipoprotein or HDL, known as good cholesterol, says Dr. R.
Optimization is much like good cholesterol, the absence of which is felt more acutely than its presence.
Big pharma is in a bad fix--and companies are increasingly turning to good cholesterol as the solution.
An experimental Pfizer drug designed to raise HDL (good cholesterol) recently increased mortality in a large clinical trial.
Raising good cholesterol is among Acomplia's salutatory effects as well, but Lipitor-torcetrapib appears to be far more potent.
It also boosted good cholesterol 24.5%, with half the benefit attributed to the drug, not the weight loss.
Basically, niacin is one of the few compounds known to raise HDL, the so-called good cholesterol, albeit modestly.
FORBES: Will Merck's Failure With Tredaptive Impact How Drugs Are Approved in Europe?
Also on tap, a new form of niacin, the only drug now available to raise HDL (the good cholesterol).
Pfizer presented data on the drug that showed that it raised good cholesterol--although by less than some analysts expected.
Fifty is the good cholesterol, the HDL -- that should be above 50.
There was, for instance, great interest by pharmaceutical companies in drugs being developed by Esperion Therapeutics to raise good cholesterol.
But much of the future of the company rests on pipeline drug torcetrapib, a pill designed to raise good cholesterol.
According to Leerink Swann, results are expected for a drug to cut triglycerides and raise good cholesterol from Eli Lilly.
Scientists have also speculated that the kind of HDL "good cholesterol" made by a drug like torcetrapib might be dysfunctional.
Levels of good cholesterol were raised by 34% among people who were given the new drug in just four weeks.
Nothing on the market today increases "good cholesterol, " or high-density lipoprotein (HDL), as much as torcetrapib did in early clinical trials.
The most promising: a pill called a CETP inhibitor, which raises good cholesterol and may reduce cardiac inflammation and heart disease.
Yet Pfizer is actually spending that much on test for one new medicine to raise good cholesterol and clear clogged arteries.
In the trial, the Merck drug caused a remarkable 138% increase in good cholesterol, pushing people up into supernormal levels above 100.
Pfizer is farthest along with a medicine that could raise good cholesterol.
Exercise is one of the most effective measures for raising good cholesterol.
The colossal failure cast a pall over the good cholesterol field and raised questions over whether doctors understand how good cholesterol works.
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