"Isolation can be a breeding ground for depression and deviancy, " said Irwin, a psychotherapist who works with court-mandated parolees and probationers in California.

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Mr Roosevelt, who took over as the Great Depression ground the confidence and vitality out of American life, was relentlessly upbeat.

BBC: Fifty days of the Obama presidency

The depression left by the blast at ground zero is barely visible.

NPR: Revisiting the Birth of the Bomb