The Nottinghamshire seamer suffered a hamstring strain in the final one-day international on Saturday.
Dewald Nel misses through injury and top bowler Gordon Goudie is struggling to recover from a hamstring strain.
Flynn suffered a hamstring strain during training in London on Monday and is a doubt for the game at Twickenham.
Playmaker Joe Cole is also sidelined as he recovers from the hamstring strain picked up at Bolton on 31 October.
England hope Jason Robinson will play still be able to play a part in the tournament, despite a hamstring strain.
"I said in the huddle, 'E, throw it up to me, '" said Nicks, who nursed a bad hamstring strain all week.
Shahzad, 24, who has played one limited overs international against Bangladesh, comes in for Nottinghamshire's Ryan Sidebottom who has a hamstring strain.
Akinfenwa limped off with a hamstring strain in the match against Accrington.
Davies suffered his hamstring strain in that win in which his kick led to wing Williams winning the race for the wing's second try.
Scottish full-back McNaughton limped off in the 18th minute after pulling up sharply with a hamstring strain and was replaced by debutant left-back Lee Naylor.
Eduardo, who came off with a slight hamstring strain midway through the second half, is set to feature heavily in Wenger's plans in the run-in.
"His serve was very good, " said Nadal, who withdrew from the men's doubles alongside Marc Lopez because of a hamstring strain in his right leg.
Lennon added that defender Glenn Loovens, linked with a possible move away from Celtic, had not been dropped, but was absent because of a hamstring strain.
Zigic came on for Spanish international striker David Villa, who limped off with a hamstring strain and looks doubtful for upcoming World Cup qualifiers next week.
Declan McCrossan will also miss the Omagh game because of a hamstring strain while Cormac McAnallen may again be ruled out because of a knee injury.
ANAHEIM, Calif. (AP) The Los Angeles Dodgers placed slumping All-Star center fielder Matt Kemp on the 15-day disabled list Thursday because of a right hamstring strain.
Meanwhile, Australian opener Matthew Hayden suffered a slight hamstring strain during the match and will undergo intensive treatment in the hope of being fit for Friday's decider.
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France lost key midfielder Patrick Vieira to a hamstring strain midway through the second half but maintained the pressure amid the tiredness as the error count rose.
Jonathan Davies' hamstring strain means James Hook moves from fly-half to centre to win his 50th cap and Stephen Jones is back for his 98th cap at 10.
Peter Hoekstra recovered from the hamstring strain which kept him out of action against Portsmouth last Saturday as the Potters looked to secure their first victory in 15 games.
Edwards played in the first four games of the season with his latest club, London Broncos, before being sidelined with a hamstring strain and has decided to take a complete break from the game.
But South African Malan was equal to the situation, receiving stubborn lower-order support as he compiled a fluent 88 from 114 balls, with 12 fours, despite suffering the hamstring strain which later prevented him from fielding.
It was the fourth time in Kemp's career that the two-time Gold Glove winner has been on the DL, including two stints last season because of a left hamstring strain that cost him a combined 51 games.
Robinson suffered a strain to his left hamstring, but he will remain with the squad to have further treatment and there is a chance he could be involved in future games.
England's bowling department has been depleted by injuries, with Ajmal Shahzad (hamstring) and Chris Tremlett (side strain) the latest casualties.
Midfielders Steven Pienaar (hamstring) and Leon Osman (stomach strain) have both missed recent games, while Anichebe was injured by a horror tackle from Kevin Nolan against Newcastle.
Zakuani is still struggling with a groin strain, while Geohaghon has a hamstring problem, Mackail-Smith has picked up a virus and Boyd has an ankle problem.
He is battling a calf strain with his replacement against City, Jonny Evans, also carrying a hamstring problem.
With Joba Chamberlain having gone on the disabled list before the game with an oblique strain and David Robertson unavailable this series because of soreness in the area where the left knee meets the hamstring, manager Joe Girardi was counting on Sabathia to go deep in the game.
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